Dynamic kinetic resolution of racemic tropic acid ethyl ester and its derivatives

Autor:	M. Mahmun Hossain, Mary Rose Atuu
Rok vydání:	2007
Předmět:	biology Organic Chemistry Substrate (chemistry) Ruthenium catalyst General Medicine Ethyl ester Biochemistry Tropic acid Catalysis Kinetic resolution Isopropenyl acetate chemistry.chemical_compound chemistry Drug Discovery biology.protein Organic chemistry Lipase
Zdroj:	Tetrahedron Letters. 48:3875-3878
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2007.03.143
Popis:	The dynamic kinetic resolution of racemic mixtures of tropic acid ethyl ester under substrate racemizing conditions was studied using lipase PS with a ruthenium catalyst. Isopropenyl acetate was used as an acyl donor, since it was found to be compatible with both catalysts; this resulted in an efficient dynamic kinetic resolution. With this process, a variety of racemic tropic acid ethyl esters were transformed to optically active acetoxy-2-arylpropionic acid ethyl esters with 60–88% yields and 53–92% ee.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a9fdcf4897aba4c8123f152735726b https://doi.org/10.1016/j.tetlet.2007.03.143 Zobrazit plný text záznamu Full Text from ScienceDirect