Native LDL-cholesterol mediated monocyte adhesion molecule overexpression is blocked by simvastatin
| Autor: | Adriano Freitas Ribeiro, Carlos V. Serrano, James A. de Lemos, Jose C. Nicolau, Vanda M. Yoshida, Antonio Eduardo Pesaro, C. Alexandre Segre, Fernando Ribeiro Gomes, Hugo P. Monteiro, Fabiana Rached |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Simvastatin CD14 Hypercholesterolemia Lipopolysaccharide Receptors Coronary Artery Disease Monocytes Proinflammatory cytokine Internal medicine medicine Humans Pharmacology (medical) L-Selectin Pharmacology CD11b Antigen biology Cell adhesion molecule business.industry Monocyte Anticholesteremic Agents General Medicine Cholesterol LDL Middle Aged Hydroxymethylglutaryl-CoA reductase medicine.anatomical_structure Endocrinology Integrin alpha M HMG-CoA reductase biology.protein Female Cardiology and Cardiovascular Medicine business Cell Adhesion Molecules medicine.drug |
| Zdroj: | Cardiovascular drugs and therapy. 23(3) |
| ISSN: | 1573-7241 |
| Popis: | This study sought to evaluate the effect of nLDL concentrations on monocyte adhesion molecule expression in hypercholesterolemic patients with stable coronary artery disease (CAD) and to determine whether lipid-lowering therapy with simvastatin would change this effect. Blood samples from patients with hypercholesterolemia (mean LDL 152 mg/dL) and CAD (HC, n = 23) were collected before and after a 12-week treatment with 40 mg of simvastatin. Healthy individuals (mean LDL 111 mg/dL) were used as controls (CT, n = 15). Isolated nLDL, at a fixed concentration of 100 mg/dL, was added to monocyte suspensions obtained before and after the simvastatin treatment. Monocyte activation was determined by changes in cellular adhesion molecule expression. In response to nLDL, CD11b and CD14 adhesion molecule expression was higher in HC patients than in CT patients before treatment (174.2 ± 8.4 vs 102.2 ± 6.3, P |
| Databáze: | OpenAIRE |
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