Antral Hypergastrinemia – A Report of Three Cases
| Autor: | E. Amdrup, Jørgen Hedemark Poulsen, P. Delikaris, L.I. Larsson |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Radioimmunoassay Peptide hormone Gastroenterology Gastric Acid Recurrence Internal medicine Gastrins Pyloric Antrum medicine Humans Stomach Ulcer Antrum Gastrin Hyperplasia business.industry digestive oral and skin physiology Middle Aged digestive system diseases Serum gastrin Endocrinology Gastrointestinal hormone Female business |
| Zdroj: | Digestion. 37:211-216 |
| ISSN: | 1421-9867 0012-2823 |
| Popis: | Three patients with juxtapyloric ulcers and hypergastrinemia are presented. Fasting and food-stimulated serum gastrin concentration (SGC) were measured in 1970, 1972 and 1973 before the primary ulcer operation (selective gastric vagotomy and Jaboulay gastroduodenostomy; SGV + GD). Fasting SGC were 105, 149 and 158 pg/ml and the postprandial concentrations were 400, greater than 800 and greater than 800 pg/ml, respectively. The pentagastrin-stimulated acid secretion was within the normal range. After SGV + GD, only a slight decrease in acid secretion was observed. The hypergastrinemia persisted unchanged or decreased slightly in 1 patient. A recurrent ulcer developed and a precise antrectomy was carried out. Postoperatively, the fasting SGC was markedly reduced and the postprandial gastrin response abolished. The resected specimens were subjected to immunocytochemical gastrin cell quantitation. The number of gastrin cells was elevated in all 3 patients and the gastrin cell topography was distorted, with cells being present both in the lower and upper thirds of the antropyloric glands. |
| Databáze: | OpenAIRE |
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