Dietary carotenoids inhibit neoplastic transformation and modulate gene expression in mouse and human cells
| Autor: | H Bortkiewicz, J S Bertram |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Keratinocytes
Cellular differentiation Medicine (miscellaneous) Cell Communication Biology medicine.disease_cause Mice Retinoids chemistry.chemical_compound Lipid oxidation medicine Animals Humans Neoplastic transformation Canthaxanthin Anticarcinogen Carotenoid Cells Cultured Regulation of gene expression chemistry.chemical_classification Nutrition and Dietetics Gap Junctions food and beverages Cell Differentiation Carotenoids Cell Transformation Neoplastic Gene Expression Regulation chemistry Biochemistry Lipid Peroxidation Carcinogenesis |
| Zdroj: | The American Journal of Clinical Nutrition. 62:1327S-1336S |
| ISSN: | 0002-9165 |
| Popis: | Many epidemiologic studies have associated the consumption of diets rich in fruit and green and yellow vegetables with a decreased risk of cancer. Of the many components of such a diet, the content of carotenoids, particularly beta-carotene, has been most consistently linked to decreased risk. The biological mechanism for such protection is currently unclear. Multiple possibilities exist: carotenoids are potent antioxidants and oxidative stress is known to contribute to carcinogenesis; many carotenoids can be converted to retinoids, these are known cancer preventive agents at several anatomic sites; and carotenoids may possess additional actions in mammalian cells. In a model in vitro system we showed that carotenoids both with and without provitamin A activity inhibit carcinogen-induced neoplastic transformation, inhibit plasma membrane lipid oxidation, and cause up-regulated expression of connexin 43, a gene coding for the structural unit of a gap junction. This last activity was statistically correlated with the ability to inhibit neoplastic transformation. Activity has also been shown in human cells: in fibroblasts CONNEXIN 43 expression is also up-regulated whereas in human keratinocytes grown in organotypic culture beta-carotene and canthaxanthin modulate differentiation in a manner qualitatively similar to that of retinoids. These results strongly suggest that carotenoids have intrinsic cancer chemopreventive action in humans. |
| Databáze: | OpenAIRE |
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