Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant
| Autor: | Christine M. Freitag, Susann Hänig, Christiane Seitz, Dirk Moser, Jobst Meyer, Anna Schneider, Haukur Palmason, Alexander Marcus, J. C. Sigmund, Christian Vogler |
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| Rok vydání: | 2009 |
| Předmět: |
Conduct Disorder
Male Oncology medicine.medical_specialty Adolescent Single-nucleotide polymorphism Comorbidity Environment Catechol O-Methyltransferase Polymorphism Single Nucleotide behavioral disciplines and activities Risk Factors Internal medicine mental disorders medicine Humans Attention deficit hyperactivity disorder SNP Family Genetic Predisposition to Disease Risk factor Child Alleles Biological Psychiatry Psychiatric Status Rating Scales Genetics Catechol-O-methyl transferase Sequence Analysis DNA medicine.disease Psychiatry and Mental health Phenotype nervous system Neurology Attention Deficit Disorder with Hyperactivity Conduct disorder Female Neurology (clinical) Psychology rs4680 |
| Zdroj: | Journal of Neural Transmission. 117:259-267 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | The catechol-O-methyltransferase gene (COMT) plays a crucial role in the metabolism of catecholamines in the frontal cortex. A single nucleotide polymorphism (Val(158)Met SNP, rs4680) leads to either methionine (Met) or valine (Val) at codon 158, resulting in a three- to fourfold reduction in COMT activity. The aim of the present study was to assess the COMT Val(158)Met SNP as a risk factor for attention-deficit/hyperactivity disorder (ADHD), ADHD symptom severity and co-morbid conduct disorder (CD) in 166 children with ADHD. The main finding of the present study is that the Met allele of the COMT Val(158)Met SNP was associated with ADHD and increased ADHD symptom severity. No association with co-morbid CD was observed. In addition, ADHD symptom severity and early adverse familial environment were positive predictors of lifetime CD. These findings support previous results implicating COMT in ADHD symptom severity and early adverse familial environment as risk factors for co-morbid CD, emphasizing the need for early intervention to prevent aggressive and maladaptive behavior progressing into CD, reducing the overall severity of the disease burden in children with ADHD. |
| Databáze: | OpenAIRE |
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