Effect of magnesium sulfate administration on subendocardial and subepicardial perfusion
| Autor: | Maria Jesus Del Cerro, Dolores Blanco, Maria Aurora Fernández Ruiz, Panayotis Fantidis, Rosario Madero Jarabo, Tom Arne Stiris |
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| Rok vydání: | 1998 |
| Předmět: |
Cardiac output
medicine.medical_specialty Swine Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Blood Pressure Biochemistry Inorganic Chemistry Magnesium Sulfate Heart Rate Internal medicine Coronary Circulation Heart rate medicine Animals Cardiac Output Radionuclide Imaging Saline Saline Solution Hypertonic business.industry Biochemistry (medical) Heart General Medicine Blood flow Microspheres medicine.anatomical_structure Blood pressure Animals Newborn Breathing Vascular resistance Cardiology Vascular Resistance Blood Gas Analysis business Perfusion |
| Zdroj: | Biological trace element research. 60(3) |
| ISSN: | 0163-4984 |
| Popis: | The objective of this study was to determine the effect of systemic MgSO4 infusion on subendocardial and subepicardial perfusion. Seventeen spontaneously breathing piglets were examined. Myocardial perfusion was measured using radiolabeled microspheres at baseline, 30 and 60 min after either MgSO4 (80 mg/kg) or saline infusion. Blood pressure, heart rate, and cardiac output were also measured at these time intervals. Comparison of the magnesium-induced changes in systemic blood pressure and on subendocardial and subepicardial perfusion at 30 and 60 min with values obtained with saline solution at 30 and 60 min, yielded no statistically significant difference (Tables 1-3). The ratio of subendocardial/subepicardial blood flow and subendocardial and subepicardial coronary vascular resistance at 30 and 60 min revealed no statistically significant differences between the magnesium and the control group (Table 3). There were no statistically significant difference in cardiac output and heart rate during any of the measured periods (Table 2). Our results suggest that the administration of MgSO4 does not alter the ratio of subendocardial/subepicardial blood flow and the ratio of subendocardial/subepicardial coronary vascular resistance. |
| Databáze: | OpenAIRE |
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