Isobologram analysis of the combined effects of anti-tumour platinum complexes and ionizing radiation on mammalian cells
| Autor: | A H Nias, I Szumiel |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Cancer Research
Radiation-Sensitizing Agents Time Factors Organoplatinum Compounds Cell Survival chemistry.chemical_element Antineoplastic Agents Cyclopentanes Biology Synergistic combination Ionizing radiation Anti tumour Cricetulus Cricetinae Animals Cells Cultured Dose-Response Relationship Drug business.industry Chinese hamster ovary cell Ovary Dose-Response Relationship Radiation Method of analysis Radiation effect In vitro Oncology chemistry Gamma Rays Biophysics Female Platinum Nuclear medicine business Mathematics Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | Chinese hamster ovary cells have been treated in vitro with the platinum coordination complexes cis-PAD or CHIP and with radiation, either alone or in combination with different doses and time intervals. The isobologram method has been used to make a graphic comparison of these combined-modality data in terms of additivity and enhancement. The data showed enhancement of the radiation effect by these platinum complexes in many combinations, and a truly synergistic effect in one case. This method of analysis points to the limited usefulness of the parameter dose-modifying effect (DMF) since the most synergistic combination did not have the highest DMF. |
| Databáze: | OpenAIRE |
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