Anxiety and anhedonia in depression: Associations with neuroticism and cognitive control
| Autor: | Christian A. Webb, Robrina Walker, Patrick J. McGrath, Allen Liao, Mary L. Phillips, Crystal Cooper, Thomas J. Carmody, Bruce D. Grannemann, Myrna M. Weissman, Phil Adams, Maurizio Fava, Gerard E. Bruder, Diego A. Pizzagalli, Daniel G. Dillon, Benji T. Kurian, Ramin V. Parsey, Melvin G. McInnis, Madhukar H. Trivedi, Meredith A. Shaw |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Anhedonia behavioral disciplines and activities Article 03 medical and health sciences Cognition 0302 clinical medicine Reward Restricted range mental disorders medicine Humans Learning Path analysis (statistics) Neuroticism Depressive Disorder Major Middle Aged medicine.disease Anxiety Disorders Antidepressive Agents 030227 psychiatry Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies Treatment Outcome Major depressive disorder Anxiety Antidepressant Female medicine.symptom Psychology psychological phenomena and processes 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | J Affect Disord |
| ISSN: | 0165-0327 |
| Popis: | BACKGROUND: Despite the fact that higher levels of anxiety and anhedonia in Major Depressive Disorder (MDD) are linked to poorer treatment outcomes, mechanisms contributing to these clinical presentations remain unclear. Neuroticism, impaired cognitive control, and blunted reward learning may be critical processes involved in MDD and may help to explain symptoms of anxiety and anhedonia. METHODS: Using baseline data from patients with early-onset MDD (N=296) in the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) trial, we conducted a path analysis to model relationships between neuroticism, cognitive control, and reward learning to levels of anxiety and anhedonia. RESULTS: Neuroticism was positively associated with both anhedonia (standardized coefficient = 0.26, p < .001) and anxiety (standardized coefficient = 0.40, p < .001). Cognitive control was negatively associated with anxiety (standardized coefficient = −0.18, p < .05). Reward learning was not significantly associated with either anxiety or anhedonia. LIMITATIONS: Extraneous variables not included in the model may have even more influence in explaining symptoms of anxiety and anhedonia. Restricted range in these variables may have attenuated some of the hypothesized relationships. Most important, because this was a cross-sectional analysis in a currently depressed sample, we cannot draw any causal conclusions without experimental and longitudinal data. CONCLUSIONS: These cross-sectional findings suggest that neuroticism may contribute to anxiety and anhedonia in patients with early onset and either chronic or recurrent MDD, while enhanced cognitive control may protect against anxiety. |
| Databáze: | OpenAIRE |
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