Catalytic Asymmetric Decarboxylative Michael Addition To Construct an All-Carbon Quaternary Center with 3-Alkenyl-oxindoles

Autor:	Yingzheng Ren, Shuhui Lu, Lin He, Zhifei Zhao, Shi-Wu Li
Rok vydání:	2022
Předmět:	Organic Chemistry Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 24:2585-2589
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.2c00411
Popis:	The first highly enantioselective asymmetric decarboxylative addition of β-keto acids with 3-alkenyl-oxindoles bearing an all-carbon quaternary stereocenter have been developed. The relevant products were acquired in 49-98% yields with 88-98% enantioselectivities in the presence of 0.04-1.0 mol % of chiral rhodium catalyst. The comprehensive practicability of this method was proven in the preparation of the key intermediate, which can be easily transformed into analogues of physovenine and physostigmine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a6f37fcc22435db52bb4fe9531d7c2 https://doi.org/10.1021/acs.orglett.2c00411 Zobrazit plný text záznamu