Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery

Autor: Mohamed Mashal, Jon Zarate, Ramon Eritja, Myriam Sainz-Ramos, Eduardo Fernández, Noha Attia, David Díaz Díaz, Gustavo Puras, Nuseibah Al Qtaish, Ramon Pons, Tania López, Santiago Grijalvo, José Luis Pedraz
Přispěvatelé: Consejo Superior de Investigaciones Científicas (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Eusko Jaurlaritza, Generalitat de Catalunya, Eritja Casadellà, Ramón [0000-0001-5383-9334], Eritja Casadellà, Ramón
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Pharmaceutics, Vol 11, Iss 2, p 50 (2019)
Addi. Archivo Digital para la Docencia y la Investigación
instname
Digital.CSIC. Repositorio Institucional del CSIC
Pharmaceutics
ISSN: 1999-4923
2017-8441
Popis: Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly of non-ionic surfactant molecules. This process can be governed not only by the nature of such surfactants but also by others factors like the presence of additives, formulation preparation and properties of the encapsulated hydrophobic or hydrophilic molecules. This review is aimed at providing recent information for using cationic niosomes for gene delivery purposes with particular emphasis on improving the transportation of antisense oligonucleotides (ASOs), small interference RNAs (siRNAs), aptamers and plasmids (pDNA).
The authors also wish to thank the intellectual and technical assistance from the ICTS “NANBIOSIS,” more specifically by the Drug Formulation Unit (U10) of the CIBER in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) at the University of Basque Country (UPV/EHU). Technical and human support provided by SGIker (UPV/EHU) is gratefully acknowledged. CIBER-BBN is an initiative funded by the VI National R + D + I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The authors also want to thank Suzanne Renée Córdova for revising this manuscript.
This research was funded by the Spanish Ministerio de Ciencia e Innovación (MICINN), grant numbers CTQ2017-84415-R, MAT2015-69967-C3-1R, CTQ2017—88948-P, CIBER-BBN, grant numbers CB06_01_0019, CB06_01_1028 and CB01_01_1053, by the Basque Country Government, grant number CGIC10/172 and the Generalitat de Catalunya, grant number 2017/SGR/114, 2017/SGR/670
We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI)
Databáze: OpenAIRE
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