Risk factors for heart disease in transfusion-dependent thalassemia: serum ferritin revisited
| Autor: | Filomena Longo, Gian Luca Forni, Maria Domenica Cappellini, Raffaella Origa, Immacolata Tartaglione, Valeria Pinto, Antonella Quarta, Patrizio Bina, Antonio Piga, Webthal, Marianna Giuditta, Carlo Dessì, Giorgio Derchi, Silverio Perrotta |
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| Přispěvatelé: | Derchi, Giorgio, Dessì, Carlo, Bina, Patrizio, Cappellini, Maria Domenica, Piga, Antonio, Perrotta, Silverio, Tartaglione, Immacolata, Giuditta, Marianna, Longo, Filomena, Origa, Raffaella, Quarta, Antonella, Pinto, Valeria, Forni, Gian Luca |
| Rok vydání: | 2018 |
| Předmět: |
Male
Multivariate analysis Heart disease medicine.medical_treatment Thalassemia 030204 cardiovascular system & hematology Gastroenterology Cohort Studies 0302 clinical medicine Retrospective Studie Risk Factors Iron overload Cumulative incidence 030212 general & internal medicine Child Serum ferritin Italy Area Under Curve Emergency Medicine Female Survival Analysi Human Adult medicine.medical_specialty Adolescent Heart Diseases Splenectomy 03 medical and health sciences Internal medicine Internal Medicine medicine Humans Transfusion dependent thalassemia Blood Transfusion Retrospective Studies Ferritin Chi-Square Distribution Ferritins ROC Curve Survival Analysis business.industry Risk Factor Retrospective cohort study medicine.disease Cohort Studie business |
| Zdroj: | Internal and Emergency Medicine. 14:365-370 |
| ISSN: | 1970-9366 1828-0447 |
| Popis: | Heart disease remains a leading cause of morbidity and mortality in transfusion-dependent thalassemia (TDT), which can be attributed to several factors but primarily develops in the setting of iron overload. This was a retrospective cohort study utilizing Webthal® patient data from five major centers across Italy. Patients without heart disease were followed-up for 10 years (2000-2010) and data were collected for demographics, splenectomy status, serum ferritin and hemoglobin levels, and comorbidities associated with heart disease. Among 379 patients analyzed (mean age 22.9 ± 5.1years, 47.8% men), 44 (cumulative incidence: 11.6%) developed heart disease during the period of observation. Splenectomy (p = 0.002) and serum ferritin level (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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