Studies towards the synthesis of (+)-ptilomycalin A; stereoselective N-acyliminium ion coupling reactions to enantiopure C-2 substituted lactams

Autor:	W. Nico Speckamp, Martin Ostendorf, Saskia Louwrier, Henk Hiemstra, Arnoud Boom
Přispěvatelé:	HIMS former research (FNWI)
Rok vydání:	1996
Předmět:	Silylation Stereochemistry Organic Chemistry Reaction type Biochemistry Enol Coupling reaction Ion chemistry.chemical_compound Enantiopure drug chemistry Drug Discovery Lactam Stereoselectivity
Zdroj:	Tetrahedron, 52, 2603-2628. Elsevier
ISSN:	0040-4020
Popis:	Highly stereoselective N -acyliminium ion coupling reactions of β-ketoester derived silyl enol ethers with enantiopure lactams derived from ( S )-malic acid are reported. This reaction type is applied in the synthesis of the enantiopure C-2 substituted lactam 27 , a plausible intermediate in a projected synthesis of ptilomycalin A.
Databáze:	OpenAIRE
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