Renal Cortical Intermediary Metabolism in the Recovery Phase of Postischemic Acute Renal Failure in the Dog
| Autor: | Alfredo Badia, M. A. Rengel, Inmaculada Montañés, José M. López-Novoa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Kidney Cortex Renal cortex Ischemia Renal function Biology urologic and male genital diseases General Biochemistry Genetics and Molecular Biology Adenosine Triphosphate Dogs Internal medicine medicine Animals Lactic Acid Kidney Renal ischemia Renal sodium reabsorption Acute Kidney Injury medicine.disease Glutamine medicine.anatomical_structure Endocrinology Renal blood flow Lactates Glomerular Filtration Rate |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-199-43363 |
| Popis: | Renal metabolism has been studied in eight dogs before and 48 hr after a 60-min period of renal ischemia induced by clamping the left renal artery with the simultaneous removal of the right kidney, and in 12 sham-operated animals. The study involved the measurement of renal uptake and production of lactate, glutamine, glutamate, alanine, ammonium, and oxygen, and the measurement of the tissue concentrations of ATP, glutamine, lactate, alpha-ketoglutarate, aspartate, and alanine in the renal cortex. Two days after a temporary renal ischemia, the remaining kidney showed a 22% decrease in glomerular filtration rate (GFR) and a 25% decrease in renal plasma flow. Fractional sodium and potassium excretions were similar to those of control dogs. Renal production or extraction of glutamine, glutamate, alanine, ammonium, and oxygen (all expressed by 100 ml of GFR) was not significantly different in basal conditions or 2 days after ischemia, but lactate extraction was reduced in postischemic kidneys (-101 +/- 29 vs -204 +/- 38 mumol/100 ml GFR in control dogs). The cortical concentrations of glutamine and glutamate were lower in postischemic than in control kidneys. No differences were found in cortical concentration of alpha-ketoglutarate, aspartate, lactate, pyruvate, or ATP, but total nucleotides and inorganic phosphate were decreased in postischemic kidneys. It is concluded that in the recovery phase of the ischemia, a decreased lactate uptake is the main metabolic change, and total ATP production is adapted to the decrease of GFR and sodium reabsorption. |
| Databáze: | OpenAIRE |
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