Diagnostic value of Chorioquick for detecting chorioamnionitis in women with premature rupture of membranes
| Autor: | Leonard Ogbonna Ajah, Lydia Ijeoma Eleje, Chukwuemeka C Okoro, Joseph Tochukwu Enebe, Euzebus Chinonye Ezugwu, Doris Ogbuokiri, Ahizechukwu C. Eke, Ifeanyichukwu U. Ezebialu, Chigozie G. Okafor, IV Onyiaorah, Samuel Robsam Ohayi, Augustine O. Asogwa, Cornelius O Ukah, Joseph I Ikechebelu, Emmanuel Onyebuchi Ugwu, Chukwudi Celestine Obiora, George Uchenna Eleje, Richard Obinwanne Egeonu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Fetal Membranes Premature Rupture Point-of-care testing Nigeria Prom Chorioamnionitis 03 medical and health sciences Young Adult 0302 clinical medicine Predictive Value of Tests Pregnancy medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study 030219 obstetrics & reproductive medicine Obstetrics business.industry Interleukin-6 Infant Newborn Obstetrics and Gynecology General Medicine medicine.disease Confidence interval Case-Control Studies Vagina Gestation Female business Premature rupture of membranes Biomarkers |
| Zdroj: | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and ObstetricsREFERENCES. 149(1) |
| ISSN: | 1879-3479 |
| Popis: | OBJECTIVE To determine the accuracy of a semi-quantitative interleukin-6 (IL-6) vaginal secretion rapid test (Chorioquick) for detecting chorioamnionitis in women with premature rupture of membranes (PROM). METHODS A prospective cohort study in five tertiary hospitals in Nigeria involved women with confirmed PROM at term and preterm PROM with or without suspected chorioamnionitis from August 1, 2017, to October 31, 2018. Cervicovaginal fluid samples were tested for chorioamnionitis using the Chorioquick test. Samples were repeated at decision to deliver. The test was considered positive if at least the indicator 'IL-6 low' of the three Chorioquick biomarkers (low, medium, high) was positive, or negative if none of the biomarkers were positive. Chorioamnionitis was histologically confirmed post-delivery using three tissue samples. Primary outcome measures were sensitivity, specificity, and accuracy. RESULTS Of 73 women, on histological confirmation, 39 were true positive and 29 were true negative (for chorioamnionitis) to the Chorioquick test at repeat assessment. Overall, the Chorioquick test had a sensitivity of 97.5% (95% confidence interval [CI] 85.3-99.9), specificity 87.9% (70.9-96.0), and accuracy 93.2% (79.5-99.1). Sub-group analysis of women |
| Databáze: | OpenAIRE |
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