Packing properties of 1-alkanols and alkanes in a phospholipid membrane

mem), was positive for small (C4-C6) 1-alkanols while it was negative for larger alcohols and all alkanes. The magnitude of DeltaV(m)(pure-->mem) ranged from about +4 cm3/mol for alcohols with an alkyl chain about half the length of the fatty acids of DMPC, to -10 to -15 cm3/mol for the alkanes and long chain alcohols. On the basis of these observations, previously published information on the structure of the membrane-solute complexes and the free volume properties of (pure) phospholipid membranes, we suggest that two effects dominate the packing properties of hydrophobic solutes in DMPC. First, perturbation of the tightly packed interfacial zone around the ester bonds and first few methylene groups of DMPC brings about a positive contribution to DeltaV(m)(pure-->mem). This effect dominates the volume behavior for alcohols like 1-butanol, 1-pentanol and 1-hexanol. More hydrophobic solutes penetrate into the membrane core, which is loosely packed. In this region, they partially occupy interstitial (or free-) volume, which bring about a denser molecular packing and generate a negative contribution to DeltaV(m)(pure-->mem). -->

ISSN:	0301-4622
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a255eae342cce8439ca81f872ca98e https://pubmed.ncbi.nlm.nih.gov/16223560
Rights:	CLOSED
Přírůstkové číslo:	edsair.doi.dedup.....a2a255eae342cce8439ca81f872ca98e
Autor:	Thomas H. Aagaard, Peter Westh, Mette N. Kristensen
Rok vydání:	2005
Předmět:	Lipid Bilayers Biophysics Phospholipid Volume change Biochemistry chemistry.chemical_compound Homologous series 1-Butanol Pentanols Phosphatidylcholine Mole Alkanes Organic chemistry Methylene Alkyl Phospholipids chemistry.chemical_classification Chemistry Organic Chemistry Crystallography Membrane Alcohols lipids (amino acids peptides and proteins) Hexanols Hydrophobic and Hydrophilic Interactions Densitometry
Zdroj:	Biophysical chemistry. 119(1)
ISSN:	0301-4622
Popis:	We have used vibrating tube densitometry to investigate the packing properties of four alkanes and a homologous series of ten alcohols in fluid-phase membranes of dimyristoyl phosphatidylcholine (DMPC). It was found that the volume change of transferring these compounds from their pure states into the membrane, DeltaV(m)(pure-->mem), was positive for small (C4-C6) 1-alkanols while it was negative for larger alcohols and all alkanes. The magnitude of DeltaV(m)(pure-->mem) ranged from about +4 cm3/mol for alcohols with an alkyl chain about half the length of the fatty acids of DMPC, to -10 to -15 cm3/mol for the alkanes and long chain alcohols. On the basis of these observations, previously published information on the structure of the membrane-solute complexes and the free volume properties of (pure) phospholipid membranes, we suggest that two effects dominate the packing properties of hydrophobic solutes in DMPC. First, perturbation of the tightly packed interfacial zone around the ester bonds and first few methylene groups of DMPC brings about a positive contribution to DeltaV(m)(pure-->mem). This effect dominates the volume behavior for alcohols like 1-butanol, 1-pentanol and 1-hexanol. More hydrophobic solutes penetrate into the membrane core, which is loosely packed. In this region, they partially occupy interstitial (or free-) volume, which bring about a denser molecular packing and generate a negative contribution to DeltaV(m)(pure-->mem).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a255eae342cce8439ca81f872ca98e https://pubmed.ncbi.nlm.nih.gov/16223560 Zobrazit plný text záznamu Full Text from ScienceDirect