Chronic diarrhea: Causes, presentation, and mangement
| Autor: | Devendra I. Mehta, Uwe Blecker, Lebenthal E |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Diarrhea
medicine.medical_specialty Protracted diarrhea High prevalence business.industry Infant Disease Rotavirus vaccine Diagnosis Differential Parenteral nutrition Chronic diarrhea Child Preschool Chronic Disease Diarrhea Infantile Pediatrics Perinatology and Child Health Immunology Fluid Therapy Humans Medicine Risk factor medicine.symptom Child business Intensive care medicine |
| Zdroj: | The Indian Journal of Pediatrics. 63:459-471 |
| ISSN: | 0973-7693 0019-5456 |
| DOI: | 10.1007/bf02905720 |
| Popis: | Important inroads are being made into understanding the pathophysiology of diarrhea. Clear understanding of key mechanisms should suggest new approaches to combat disease. Exciting developments are occurring in terms of super-ORS solutions, particularly with the promise of short chained glucose polymers and glutamine. Perhaps the most important development is the prospect of a good rotavirus vaccine being available before the end of the decade. Chronic diarrhea seems to be on the increase globally, probably because of the success of ORS. The mechanisms that lead to mucosal injury are elusive, and therapy still largely supportive and empiric. Celiac disease continues to be a puzzle, because of the uncomfortable feeling that a majority of cases may be missed because of atypical presentations. The successful use of long term parenteral nutrition has allowed survival and better characterization of cases that otherwise would have perished as 'lethal protracted diarrhea'. Microvillus inclusion disease may be the commonest congenital secretory diarrhea. The role of the recently reported high prevalence of glucoamlase deficiency may be important. Lastly, attention to micronutrients, particularly low vitamin A and probably zinc may prove to be important in prevention and amelioration of diarrhea and growth failure. |
| Databáze: | OpenAIRE |
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