Changes of expression of endogenous sugar receptors by polymorphonuclear leukocytes after prolonged anaesthesia and surgery
| Autor: | Attila Bardosi, Laszlo Bardosi, Hans-Joachim Gabius |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Time Factors Neutrophils medicine.medical_treatment Nitrous Oxide Asialoglycoproteins Endogeny Lactose Receptors Cell Surface Succinylcholine Granulocyte Anesthesia General Acetylglucosamine Leukocyte Count Antigen Cell surface receptor Stress Physiological White blood cell medicine Humans Receptor Fetuins Maltose Fucose Glycoproteins chemistry.chemical_classification Xylose business.industry Immunosuppression General Medicine Organ Transplantation N-Acetylneuraminic Acid Surgery Fentanyl Anesthesiology and Pain Medicine medicine.anatomical_structure chemistry Alcuronium Anesthesia Immunology Sialic Acids Carbohydrate Metabolism alpha-Fetoproteins Glycoprotein business Halothane Mannose Granulocytes |
| Zdroj: | Canadian journal of anaesthesia = Journal canadien d'anesthesie. 39(2) |
| ISSN: | 0832-610X |
| Popis: | Anaesthesia and surgery are known to depress granulocyte function in the early postoperative period, leading to deterioration of the immune defence against infection. Carbohydrate-lectin interactions may play an important role in the activities of phagocytic cells in that they facilitate initial host defence in the event of microbial antigenic challenge. A panel of biotinylated (neo)glycoproteins (chemically glycosilated carrier proteins) was used to detect endogenous carbohydrate-binding receptors /lectins/, on peripheral blood polymorphonuclear leukocytes of patients undergoing prolonged anaesthesia for replantation surgery. Four hours after induction of anaesthesia, a progressive decline of expression of endogenous sugar receptors on granulocytes was detected using the labelled (neo)glycoproteins lactose-BSA, N-acetyl-D-glucosamine-BSA, D-mannose-BSA, sialic-acid-BSA and D-xylose-BSA. Concomitant changes in peripheral white blood cell counts and the lack of depression in the absence of general anaesthetic agents suggested the existence of a possible relationship between reduced expression of (neo)glycoprotein receptors to impaired granulocyte function and anaesthetic-induced immunodepression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink