True Precocious Puberty Following Treatment of a Leydig Cell Tumor: Two Case Reports and Literature Review
| Autor: | Laura Lucchetti, Paolo Giovenali, Alberto Verrotti, Laura Penta, Pierpaolo De Feo, Letizia Zenzeri |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
endocrine system Case Report Leydig cell tumour Pediatrics GnRH analogues Internal medicine GnRH stimulation test Medicine Precocious puberty Leydig cell Medical treatment business.industry leydig cell tumor precocious pseudopuberty true precocious puberty gnrh stimulation test gnrh analogs lcsh:RJ1-570 lcsh:Pediatrics GnRH analogs medicine.disease Leydig cell tumor Precocious pseudopuberty medicine.anatomical_structure Endocrinology Leydig Cell Tumor True Precocious Puberty Pediatrics Perinatology and Child Health True precocious puberty business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Frontiers in Pediatrics, Vol 3 (2015) Frontiers in Pediatrics |
| Popis: | Leydig cell testicular tumours are a rare cause of precocious pseudopuberty in boys. Surgery is the main therapy and shows good overall prognosis. The physical signs of precocious puberty are expected to disappear shortly after surgical removal of the mass. We report two children, 7.5 and 7.7 year-old boys, who underwent testis-sparing surgery for a Leydig cell testicular tumour causing precocious pseudopuberty. During follow-up, after an immediate clinical and laboratory regression, both boys presented signs of precocious puberty and ultimately developed central precocious puberty. They were successfully treated with gonadotropin releasing hormone analogues. Only 6 other cases have been described regarding the development of central precocious puberty after successful treatment of a Leydig cell tumour causing precocious pseudo puberty. Gonadotropin-dependent precocious puberty should be considered in children treated for a Leydig cell tumour presenting persistent or recurrent physical signs of puberty activation. In such cases, therapy with gonadotropin releasing hormone analogues appears to be the most effective medical treatment. |
| Databáze: | OpenAIRE |
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