Physical activity and dietary interventions in diabetic neuropathy: a systematic review
| Autor: | Lindsay A. Zilliox, James W. Russell |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Diabetic neuropathy 030204 cardiovascular system & hematology Article law.invention 03 medical and health sciences 0302 clinical medicine Diabetic Neuropathies Randomized controlled trial law Internal medicine Diabetes mellitus medicine Animals Humans Prediabetes Exercise Endocrine and Autonomic Systems business.industry Type 2 Diabetes Mellitus Dysautonomia Overweight medicine.disease Peripheral neuropathy Diabetes Mellitus Type 2 Neurology (clinical) Diet Healthy Metabolic syndrome medicine.symptom business Risk Reduction Behavior 030217 neurology & neurosurgery |
| Zdroj: | Clin Auton Res |
| ISSN: | 1619-1560 0959-9851 |
| DOI: | 10.1007/s10286-019-00607-x |
| Popis: | PURPOSE: Diabetic neuropathy is a common and disabling disorder and there are currently no proven effective disease modifying treatments. Physical activity and dietary interventions in patients with diabetes and diabetic neuropathy have multiple beneficial effects and are generally low risk, which makes lifestyle interventions an attractive treatment option. We reviewed the literature on the effects of physical activity and dietary interventions on length dependent peripheral neuropathy and cardiac autonomic neuropathy in diabetes. METHODS: The electronic database Pubmed was systematically searched for original human and mouse model studies examining the effect of either dietary or physical activity interventions in subjects with diabetes, prediabetes, or metabolic syndrome. RESULTS: Twenty studies are included in this review. Fourteen studies were human studies and six were in mice. Studies were generally small with few controlled trials and there are no widely agreed upon outcome measures. CONCLUSIONS: Recent research indicates that dietary interventions are effective in modifying diabetic neuropathy in animal models and there is promising data that they may also ameliorate diabetic neuropathy in humans. It has been known for some time that lifestyle interventions can prevent the development of diabetic neuropathy in type 2 diabetes mellitus subjects. However, there is emerging evidence that lifestyle interventions are effective in individuals with established diabetic neuropathy. In addition to the observed clinical value of lifestyle interventions, there is emerging evidence of effects on biochemical pathways that improve muscle function and effect other organ systems including the peripheral nerve. However, data from randomized control trials is needed. |
| Databáze: | OpenAIRE |
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