The influence of pregnancy on human immunodeficiency virus type 1 infection: Antepartum and postpartum changes in human immunodeficiency virus type 1 viral load
| Autor: | Richard M. Mitchell, David N. Burns, Anne Willoughby, James J. Goedert, Arye Rubinstein, David Wright, Howard Minkoff, Sheldon Landesman, David D. Waters |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Polymerase Chain Reaction Virus Cohort Studies Acquired immunodeficiency syndrome (AIDS) Pregnancy Humans Medicine Pregnancy Complications Infectious Sida Acquired Immunodeficiency Syndrome biology business.industry Obstetrics and Gynecology Viral Load medicine.disease biology.organism_classification Virology Infectious Disease Transmission Vertical Lentivirus HIV-1 RNA Viral Gestation Female Viral disease business Viral load |
| Zdroj: | American Journal of Obstetrics and Gynecology. 178:355-359 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/s0002-9378(98)80025-2 |
| Popis: | Objective: Our objective was to examine the influence of pregnancy on human immunodeficiency virus type 1 viral load by measuring human immunodeficiency virus type 1 ribonucleic acid levels during pregnancy and post partum. Study Design: One or more plasma or serum specimens obtained before and during the third trimester, and at 2, 12, and 24 months post partum were available for 160 human immunodeficiency virus type 1-seropositve women enrolled in the Mothers and Infants Cohort Study between January 1986 and January 1991. All specimens were frozen and stored at −70°C until analyzed in batch for human immunodeficiency virus type 1 ribonucleic acid by polymerase chain reaction. A multivariate longitudinal random effects model was developed to examine changes in human immunodeficiency virus type 1 ribonucleic acid levels over time. Results: Overall, human immunodeficiency virus type 1 ribonucleic acid levels rose significantly during the study period, particularly during the second year post partum (mean, 0.09 log per year; 95% confidence interval, 0.03 to 0.15 logs per year; p =0.005). However, the mean slope during pregnancy was not significantly different from zero ( p =0.65). Conclusion: Pregnancy had little immediate effect on human immunodeficiency virus type 1 viral load in most human immunodeficiency virus type 1-seropositive women. |
| Databáze: | OpenAIRE |
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