Serum Biomarkers Related to Glucocorticoid-Induced Osteonecrosis of the Femoral Head: A Prospective Nested Case-Control Study
| Autor: | Chang Jiang, Bingxuan Hua, Zuoqin Yan, Zong‐Fei Ji, Wenshuai Fan, Hengfeng Yuan, Zhe Wang, Liang Zhu, Wang Xinyuan |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Apolipoprotein B Adolescent 0206 medical engineering 02 engineering and technology Gastroenterology 03 medical and health sciences Femoral head Young Adult 0302 clinical medicine N-terminal telopeptide Serum biomarkers Femur Head Necrosis Internal medicine medicine Humans Orthopedics and Sports Medicine Prospective Studies Prospective cohort study Glucocorticoids 030203 arthritis & rheumatology Individual susceptibility biology business.industry Middle Aged 020601 biomedical engineering medicine.anatomical_structure Case-Control Studies Nested case-control study biology.protein business Glucocorticoid Biomarkers medicine.drug |
| Zdroj: | Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 37(11) |
| ISSN: | 1554-527X |
| Popis: | Early diagnosis and prevention of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH) continues to be a challenging problem for clinicians and researchers. However, the role of circulating biomarkers for GC-induced ONFH, which may reveal individual susceptibility and facilitate earlier diagnosis, remains to be determined. The aim of this study was to identify potential biomarkers that may predict early GC-induced ONFH. A total of 123 patients scheduled for initial systemic GC therapy were enrolled in this prospective nested case-control study. The serum concentrations of 13 potential biomarkers were measured in seven patients with GC-induced ONFH, diagnosed instantly after short-term use of GCs and in 20 controls who did not develop osteonecrosis despite similar GC therapy. Biomarkers were measured both before and after taking GCs to identify any differences in marker levels and the changes during GC therapy between two groups. Type I collagen cross-linked C-telopeptide (β-CTX; p = 0.000) was significantly lower, high-density lipoprotein cholesterol (p = 0.092) and apolipoprotein (apo)-B/apo-A1 (p = 0.085) tended to be lower and higher, respectively, before GC treatment in osteonecrosis group. After GC therapy, β-CTX (p = 0.014) was significantly lower and amino terminal telopeptide of procollagen type I (PINP; p = 0.068) tended to be lower in the osteonecrosis group. As secondary outcomes, we observed remarkable changes in nine potential biomarkers following short-term GC therapy in both groups. In conclusion, we found that β-CTX, could potentially be used to predict GC-induced ONFH before GC therapy. Lower β-CTX and PINP are promising biomarkers for the early diagnosis of GC-induced ONFH. These findings need to be confirmed in large-scale prospective studies. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2348-2357, 2019. |
| Databáze: | OpenAIRE |
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