Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, 2000-2012
| Autor: | Åke Svensson, Carina Bjartling, Sinja Kristiansen, Linda Drevin, Ola Forslund, Christian Torbrand |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Dermatology Risk Assessment Organ transplantation Genital warts 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors medicine Penile cancer Humans Registries Risk factor Penile Neoplasms Aged CIS Aged 80 and over Sweden lichen planus business.industry penile intraepithelial neoplasia Balanitis General Medicine Odds ratio Middle Aged penile cancer medicine.disease PeIN RL1-803 030220 oncology & carcinogenesis Case-Control Studies Cohort Penile Intraepithelial Neoplasia business Carcinoma in Situ penile cancer in situ |
| Zdroj: | Acta Dermato-Venereologica, Vol 99, Iss 3, Pp 315-320 (2018) |
| ISSN: | 1651-2057 |
| Popis: | Studies on risk factors for penile intraepithelial neoplasia have been small in size, have not distinguished penile intraepithelial neoplasia from invasive cancer, and have relied on self-reported information. This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using information from 7 Swedish registers. Cases with penile intraepithelial neoplasia had increased odds ratios (ORs) for inflammatory skin diseases (14.7, 95% CI 6.5–33.4) including lichen planus (12.0, 95% CI 3.0–48.0), indicating lichen planus to be an important risk factor. Increased ORs were also observed for diseases of the prepuce (4.0, 95% CI 2.2–7.4), immunosuppressive drugs (5.0, 95% CI 2.5–9.8), penile surgical procedures (4.8, 95% CI 2.2–10.8), balanitis (9.2, 95% CI 5.0–16.8), genital warts (9.9, 95% CI 4.3−22.7) and organ transplantation (7.0, 95% CI 2.4–20.8). This study demonstrates important risk factors for penile intraepithelial neoplasia, providing knowledge that can help prevent the development of penile cancer. |
| Databáze: | OpenAIRE |
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