Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine
| Autor: | M Dreisbach, Y J Bryson, V M Millet |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Central Nervous System Male Chlorpheniramine Adolescent Rimantadine Adamantane Central nervous system Pharmacology Placebo Double blind chemistry.chemical_compound Double-Blind Method Amantadine medicine Humans Pharmacology (medical) Clinical Trials as Topic business.industry Infectious Diseases medicine.anatomical_structure chemistry Anesthesia Female business Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 21:1-4 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.21.1.1 |
| Popis: | A total of 52 healthy, adult volunteers were randomly assigned to five treatment groups to be treated twice daily for 4 days with 100 mg of amantadine, 100 mg of rimantadine, 4 mg of chlorpheniramine or placebo alone, or 100 mg of amantadine in combination with chlorpheniramine. The results of tests measuring performance on tasks of attention, reasoning, and memory were unaffected by treatment. Subjective side effects in recipients of amantadine, rimantadine, and chlorpheniramine were comparable and minimal. Side effects appeared to be enhanced in subjects receiving both amantadine and chlorpheniramine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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