Regulatory T Cell–Derived IL-10 Ameliorates Crescentic GN
| Autor: | Annette Erhardt, Claudia Wegscheid, Richard A. Flavell, Ulf Panzer, Gisa Tiegs, Annett Ostmann, Samuel Huber, Sonja Kapffer, Hans-Joachim Paust |
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| Rok vydání: | 2013 |
| Předmět: |
Regulatory T cell
chemical and pharmacologic phenomena Spleen Biology Kidney Severity of Illness Index T-Lymphocytes Regulatory Mice Glomerulonephritis Immune system medicine Animals RNA Messenger Mice Knockout B-Lymphocytes Sheep Macrophages FOXP3 Forkhead Transcription Factors hemic and immune systems Blood Proteins Dendritic Cells General Medicine Th1 Cells medicine.disease Blood proteins Interleukin-10 Mice Inbred C57BL Disease Models Animal Interleukin 10 Basic Research medicine.anatomical_structure Nephrology Immunology Th17 Cells |
| Zdroj: | Journal of the American Society of Nephrology. 24:930-942 |
| ISSN: | 1046-6673 |
| Popis: | Regulatory T cells (Tregs) exert their immunosuppressive activity through several immunoregulatory mechanisms, including the production of anti-inflammatory cytokines such as IL-10. Although several studies suggest a role for Tregs in modulating crescentic GN, the underlying mechanisms are not well understood. Here, using IL-10 reporter mice, we detected IL-10-producing Foxp3(+) T cells in the kidney, blood, and secondary lymphoid tissue in a mouse model of crescentic GN. Specific inactivation of Il10 in Foxp3(+) Tregs eliminated the ability of these cells to suppress renal and systemic production of IFNγ and IL-17; these IL-10-deficient Tregs lost their capacity to attenuate renal tissue injury. These data highlight the suppressive functions of Tregs in crescentic GN and suggest the importance of Treg-derived IL-10 in ameliorating disease severity and in modulating both the Th1 and most notably Th17 immune response. |
| Databáze: | OpenAIRE |
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