Chaperones for dancing on chromatin: Role of post-translational modifications in dynamic damage detection hand-offs during nucleotide excision repair
| Autor: | Brittani L Schnable, Namrata Kumar, Bennett Van Houten |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
DNA Repair DNA damage DNA repair Ultraviolet Rays Ubiquitination Biology General Biochemistry Genetics and Molecular Biology Chromatin Cell biology DNA-Binding Proteins 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Proteasome Ubiquitin chemistry Transcription factor II H biology.protein 030217 neurology & neurosurgery DNA 030304 developmental biology Nucleotide excision repair DNA Damage |
| Zdroj: | BioEssays : news and reviews in molecular, cellular and developmental biology. 43(5) |
| ISSN: | 1521-1878 |
| Popis: | We highlight a recent study exploring the hand-off of UV damage to several key nucleotide excision repair (NER) proteins in the cascade: UV-DDB, XPC and TFIIH. The delicate dance of DNA repair proteins is choreographed by the dynamic hand-off of DNA damage from one recognition complex to another damage verification protein or set of proteins. These DNA transactions on chromatin are strictly chaperoned by post-translational modifications (PTM). This new study examines the role that ubiquitylation and subsequent DDB2 degradation has during this process. In total, this study suggests an intricate cellular timer mechanism that under normal conditions DDB2 helps recruit and ubiquitylate XPC, stabilizing XPC at damaged sites. If DDB2 persists at damaged sites too long, it is turned over by auto-ubiquitylation and removed from DNA by the action of VCP/p97 for degradation in the 26S proteosome. |
| Databáze: | OpenAIRE |
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