Adiponectin, markers of subclinical inflammation and nerve conduction in individuals with recently diagnosed type 1 and type 2 diabetes
| Autor: | Imke Schamarek, Christian Herder, Bettina Nowotny, Maren Carstensen-Kirberg, Klaus Straßburger, Peter Nowotny, Alexander Strom, Sonja Püttgen, Karsten Müssig, Julia Szendroedi, Michael Roden, Dan Ziegler |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Neural Conduction 030209 endocrinology & metabolism Sural nerve Type 2 diabetes 030204 cardiovascular system & hematology Cohort Studies Pathogenesis Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetic Neuropathies Sural Nerve Germany Internal medicine Diabetes mellitus Humans Medicine Young adult Aged Inflammation Motor Neurons Type 1 diabetes Adiponectin business.industry General Medicine Middle Aged medicine.disease Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Asymptomatic Diseases Cohort Female Inflammation Mediators business Biomarkers |
| Zdroj: | European Journal of Endocrinology. 174:433-443 |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | ObjectiveSubclinical inflammation has been implicated in the development of diabetic sensorimotor polyneuropathy (DSPN), but studies using electrophysiological assessment as outcomes are scarce. Therefore, we aimed to investigate associations of biomarkers reflecting different aspects of subclinical inflammation with motor and sensory nerve conduction velocity (NCV) in individuals with diabetes.Design and methodsMotor and sensory NCV was assessed in individuals with recently diagnosed type 2 (n=352) or type 1 diabetes (n=161) from the baseline cohort of the observational German Diabetes Study. NCV sum scores were calculated for median, ulnar and peroneal motor as well as median, ulnar and sural sensory nerves. Associations between inflammation-related biomarkers, DSPN and NCV sum scores were estimated using multiple regression models.ResultsIn type 2 diabetes, high serum interleukin (IL)-6 was associated with the presence of DSPN and reduced motor NCV. Moreover, higher levels of high-molecular weight (HMW) adiponectin, total adiponectin and their ratio were associated with prevalent DSPN and both diminished motor and sensory NCV, whereas no consistent associations were observed for C-reactive protein, IL18, soluble intercellular adhesion molecule-1 and E-selectin. In type 1 diabetes, only HMW and total adiponectin showed positive associations with motor NCV.ConclusionsOur results point to a link between IL6 and both DSPN and slowed motor NCV in recently diagnosed type 2 diabetes. The reverse associations between adiponectin and NCV in type 1 and type 2 diabetes are intriguing, and further studies should explore whether they may reflect differences in the pathogenesis of DSPN in both diabetes types. |
| Databáze: | OpenAIRE |
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