Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

Autor: Cristina Vázquez-Carballo, Sergio Mezzano, Jesús Egido, Ana Belen Sanz, Sebastian Mas, Sandra Rayego-Mateos, Carmen Gomez-Guerrero, José Luis Morgado-Pascual, Lucas Opazo-Ríos, Cristina García-Caballero, Melania Guerrero-Hue, Juan Antonio Moreno, Carmen Herencia
Přispěvatelé: [Rayego-Mateos,S, Guerrero-Hue,M, García-Caballero,C, Moreno,JA] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. [Morgado-Pascual,JL, Opazo-Ríos,L, Vázquez-Carballo,C, Mas,S, Sanz,AB, Herencia,C, Gómez-Guerrero,C, Egido,J] Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain. [Opazo-Ríos,L, Egido,J] Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain. [Mezzano,S] Laboratorio de Nefrología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile. [Moreno,JA] Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain. [Moreno,JA] Hospital Universitario Reina Sofía, Córdoba, Spain., The authors work has been supported by grants from Instituto de Salud Carlos III (ISCIII, FIS-FEDER PI17/00130, PI17/01495, PI19/00588, ERA-PerMed-JTC2018-PERSTIGAN AC18/00071), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) and Cardiovascular (CIBERCV), Fondecyt Project (No. 1160465), Spanish Ministry of Science and Innovation (RTI2018-098788-B-100, DTS17/00203, DTS19/00093, RYC-2017-22369), and Spanish Societies of Cardiology (SEC), Nephrology (SEN) and Atherosclerosis (SEA). The 'PFIS' and 'Sara Borrell' training program of the ISCIII supported the salary of MGH (FI18/00310), SR-M (CD19/00021) and CH-B (CP16/00017). Córdoba University supported the salary of C.G.C., UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Chemokine
Terapéutica
Anti-Inflammatory Agents
Type 2 diabetes
Disease
Review
Diabetic nephropathy
urologic and male genital diseases
drugs
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
lcsh:Chemistry
And therapy
0302 clinical medicine
Chronic kidney disease
Organisms::Eukaryota::Animals [Medical Subject Headings]
Diabetic Nephropathies
Insuficiencia renal crónica
lcsh:QH301-705.5
Spectroscopy
Proteinuria
biology
Cell adhesion molecule
Drugs
General Medicine
Chemicals and Drugs::Pharmaceutical Preparations [Medical Subject Headings]
3. Good health
Computer Science Applications
Diabetes mellitus tipo 2
030220 oncology & carcinogenesis
type 2 diabetes
medicine.symptom
Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors::Immunosuppressive Agents [Medical Subject Headings]
Immunosuppressive Agents
Medicina
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Therapeutics [Medical Subject Headings]
Inflammation
Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Nephropathies [Medical Subject Headings]
Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents [Medical Subject Headings]
Catalysis
Inorganic Chemistry
03 medical and health sciences
medicine
Animals
Humans
Hypoglycemic Agents
Physical and Theoretical Chemistry
Molecular Biology
Inflamación
business.industry
diabetic nephropathy
Organic Chemistry
Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus
Type 2 [Medical Subject Headings]
and therapy
medicine.disease
030104 developmental biology
Nefropatías diabéticas
lcsh:Biology (General)
lcsh:QD1-999
Preparaciones farmacéuticas
inflammation
Immunology
biology.protein
Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agents [Medical Subject Headings]
Therapy
business
Diseases::Pathological Conditions
Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings]
chronic kidney disease
Kidney disease
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 3798, p 3798 (2020)
International Journal of Molecular Sciences 21(11), 3798 (2020)
Helvia. Repositorio Institucional de la Universidad de Córdoba
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
International Journal of Molecular Sciences
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
ISSN: 1661-6596
1422-0067
Popis: Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting in elevated cost for public health systems. DN is the main cause of chronic kidney disease (CKD) and its incidence increases the number of patients that develop the end-stage renal disease (ESRD). There are growing epidemiological and preclinical evidence about the close relationship between inflammatory response and the occurrence and progression of DN. Several antiinflammatory strategies targeting specific inflammatory mediators (cell adhesion molecules, chemokines and cytokines) and intracellular signaling pathways have shown beneficial effects in experimental models of DN, decreasing proteinuria and renal lesions. A number of inflammatory molecules have been shown useful to identify diabetic patients at high risk of developing renal complications. In this review, we focus on the key role of inflammation in the genesis and progression of DN, with a special interest in effector molecules and activated intracellular pathways leading to renal damage, as well as a comprehensive update of new therapeutic strategies targeting inflammation to prevent and/or retard renal injury.
The authors work has been supported by grants from Instituto de Salud Carlos III (ISCIII, FIS-FEDER PI17/00130, PI17/01495, PI19/00588, ERA-PerMed-JTC2018-PERSTIGAN AC18/00071), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) and Cardiovascular (CIBERCV), Fondecyt Project (No. 1160465), Spanish Ministry of Science and Innovation (RTI2018-098788-B-100, DTS17/00203, DTS19/00093, RYC-2017-22369), and Spanish Societies of Cardiology (SEC), Nephrology (SEN) and Atherosclerosis (SEA). The “PFIS” and “Sara Borrell” training program of the ISCIII supported the salary of MGH (FI18/00310), SR-M (CD19/00021) and CH-B (CP16/00017). Córdoba University supported the salary of C.G.C.
Databáze: OpenAIRE
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