Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy
Autor: | Cristina Vázquez-Carballo, Sergio Mezzano, Jesús Egido, Ana Belen Sanz, Sebastian Mas, Sandra Rayego-Mateos, Carmen Gomez-Guerrero, José Luis Morgado-Pascual, Lucas Opazo-Ríos, Cristina García-Caballero, Melania Guerrero-Hue, Juan Antonio Moreno, Carmen Herencia |
---|---|
Přispěvatelé: | [Rayego-Mateos,S, Guerrero-Hue,M, García-Caballero,C, Moreno,JA] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. [Morgado-Pascual,JL, Opazo-Ríos,L, Vázquez-Carballo,C, Mas,S, Sanz,AB, Herencia,C, Gómez-Guerrero,C, Egido,J] Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain. [Opazo-Ríos,L, Egido,J] Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain. [Mezzano,S] Laboratorio de Nefrología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile. [Moreno,JA] Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain. [Moreno,JA] Hospital Universitario Reina Sofía, Córdoba, Spain., The authors work has been supported by grants from Instituto de Salud Carlos III (ISCIII, FIS-FEDER PI17/00130, PI17/01495, PI19/00588, ERA-PerMed-JTC2018-PERSTIGAN AC18/00071), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) and Cardiovascular (CIBERCV), Fondecyt Project (No. 1160465), Spanish Ministry of Science and Innovation (RTI2018-098788-B-100, DTS17/00203, DTS19/00093, RYC-2017-22369), and Spanish Societies of Cardiology (SEC), Nephrology (SEN) and Atherosclerosis (SEA). The 'PFIS' and 'Sara Borrell' training program of the ISCIII supported the salary of MGH (FI18/00310), SR-M (CD19/00021) and CH-B (CP16/00017). Córdoba University supported the salary of C.G.C., UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD) |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Chemokine Terapéutica Anti-Inflammatory Agents Type 2 diabetes Disease Review Diabetic nephropathy urologic and male genital diseases drugs Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] lcsh:Chemistry And therapy 0302 clinical medicine Chronic kidney disease Organisms::Eukaryota::Animals [Medical Subject Headings] Diabetic Nephropathies Insuficiencia renal crónica lcsh:QH301-705.5 Spectroscopy Proteinuria biology Cell adhesion molecule Drugs General Medicine Chemicals and Drugs::Pharmaceutical Preparations [Medical Subject Headings] 3. Good health Computer Science Applications Diabetes mellitus tipo 2 030220 oncology & carcinogenesis type 2 diabetes medicine.symptom Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors::Immunosuppressive Agents [Medical Subject Headings] Immunosuppressive Agents Medicina Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics [Medical Subject Headings] Inflammation Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Nephropathies [Medical Subject Headings] Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents [Medical Subject Headings] Catalysis Inorganic Chemistry 03 medical and health sciences medicine Animals Humans Hypoglycemic Agents Physical and Theoretical Chemistry Molecular Biology Inflamación business.industry diabetic nephropathy Organic Chemistry Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus Type 2 [Medical Subject Headings] and therapy medicine.disease 030104 developmental biology Nefropatías diabéticas lcsh:Biology (General) lcsh:QD1-999 Preparaciones farmacéuticas inflammation Immunology biology.protein Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agents [Medical Subject Headings] Therapy business Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings] chronic kidney disease Kidney disease |
Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 3798, p 3798 (2020) International Journal of Molecular Sciences 21(11), 3798 (2020) Helvia. Repositorio Institucional de la Universidad de Córdoba instname Biblos-e Archivo. Repositorio Institucional de la UAM International Journal of Molecular Sciences Biblos-e Archivo: Repositorio Institucional de la UAM Universidad Autónoma de Madrid |
ISSN: | 1661-6596 1422-0067 |
Popis: | Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting in elevated cost for public health systems. DN is the main cause of chronic kidney disease (CKD) and its incidence increases the number of patients that develop the end-stage renal disease (ESRD). There are growing epidemiological and preclinical evidence about the close relationship between inflammatory response and the occurrence and progression of DN. Several antiinflammatory strategies targeting specific inflammatory mediators (cell adhesion molecules, chemokines and cytokines) and intracellular signaling pathways have shown beneficial effects in experimental models of DN, decreasing proteinuria and renal lesions. A number of inflammatory molecules have been shown useful to identify diabetic patients at high risk of developing renal complications. In this review, we focus on the key role of inflammation in the genesis and progression of DN, with a special interest in effector molecules and activated intracellular pathways leading to renal damage, as well as a comprehensive update of new therapeutic strategies targeting inflammation to prevent and/or retard renal injury. The authors work has been supported by grants from Instituto de Salud Carlos III (ISCIII, FIS-FEDER PI17/00130, PI17/01495, PI19/00588, ERA-PerMed-JTC2018-PERSTIGAN AC18/00071), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) and Cardiovascular (CIBERCV), Fondecyt Project (No. 1160465), Spanish Ministry of Science and Innovation (RTI2018-098788-B-100, DTS17/00203, DTS19/00093, RYC-2017-22369), and Spanish Societies of Cardiology (SEC), Nephrology (SEN) and Atherosclerosis (SEA). The “PFIS” and “Sara Borrell” training program of the ISCIII supported the salary of MGH (FI18/00310), SR-M (CD19/00021) and CH-B (CP16/00017). Córdoba University supported the salary of C.G.C. |
Databáze: | OpenAIRE |
Externí odkaz: |