The Avian Transcription Factor c-Rel is Expressed in Lymphocyte Precursor Cells and Antigen-Presenting Cells During Thymus Development
| Autor: | Fatima Bouali, P J Enrietto, D Stehelin, B Vandenbunder, Corinne Abbadie, Christelle Huguet |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Cytoplasm animal structures Lymphocyte Cellular differentiation Immunology Immunocytochemistry Blotting Western Rel/NF-κB Chick Embryo Thymus Gland Biology Antigen NF-KappaB Inhibitor alpha thymus Proto-Oncogene Proteins medicine avian development Animals antigen-presenting cells Tissue Distribution Lymphocytes Antigen-presenting cell Cell Nucleus NF-kappa B Cell Differentiation Hematopoietic Stem Cells Molecular biology Immunohistochemistry Proto-Oncogene Proteins c-rel Cell biology Cell Compartmentation DNA-Binding Proteins IκBα medicine.anatomical_structure lymphocyte precursor cells embryonic structures I-kappa B Proteins REL lcsh:RC581-607 Cell Division Developmental Biology Research Article Transcription Factors |
| Zdroj: | Clinical and Developmental Immunology, Vol 5, Iss 4, Pp 247-261 (1998) Developmental Immunology |
| ISSN: | 1044-6672 |
| DOI: | 10.1155/1998/58608 |
| Popis: | Transcription factors of the Rel/NF-κB family are widely involved in the immune system. In this study, we investigate thein vivoexpression of the avian protein c-Rel in the T-cell lineage during thymus development. The majority of thymocytes do not express the c-Rel protein. However, lymphocyte precursor cells that colonize the thymus express the c-Rel protein shortly after their homing in the organ and before they begin to differentiate, c-Rel is also detected in different subsets of,antigen-presenting cells such as epithelial cells, dendritic cells, and macrophages.In vitrostudies have shown that Rel/NF-κB proteins are sequestered in an inactive form in the cytoplasm by interaction with the IκBαinhibitory protein. By immunocytochemistry, we show thatin vivoc-Rel is localized in the cytoplasm of antigen-presenting cells but in both the cytoplasm and nucleus of lymphocyte precursor cells. The cytoplasmic localization of c-Rel in antigen-presenting cells correlates with a high expression of IκBα, whereas the nuclear localization of c-Rel in lymphocyte precursor cells correlates with a much lower expression of IκBα. These results suggest that c-Rel might be constitutively activated in lymphocyte precursor cells. |
| Databáze: | OpenAIRE |
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