Prevalence of Ocular Surface Complaints in Patients With Glaucoma Using Topical Intraocular Pressure-Lowering Medications
| Autor: | Mark C Jasek, David G. Godfrey, William C. Stewart, Donald L. Budenz, Robert D. Fechtner, Jeanette A. Stewart |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Intraocular pressure medicine.medical_specialty genetic structures Administration Topical Glaucoma Ocular hypertension Corneal Diseases Surveys and Questionnaires Ophthalmology Prevalence Humans Medicine In patient Prospective Studies Prospective cohort study Antihypertensive Agents Intraocular Pressure Aged Ocular surface disease business.industry medicine.disease eye diseases Dry Eye Syndromes Female Ocular Hypertension Observational study sense organs Ophthalmic Solutions business Ocular surface Glaucoma Open-Angle |
| Zdroj: | Cornea. 29:618-621 |
| ISSN: | 0277-3740 |
| DOI: | 10.1097/ico.0b013e3181c325b2 |
| Popis: | To determine the prevalence of ocular surface disease (OSD) in patients with glaucoma using topical intraocular pressure (IOP)-lowering therapy.This prospective observational study enrolled patients with primary open-angle glaucoma or ocular hypertension who were on a topical IOP-lowering medication regimen. Enrolled patients completed the ocular surface disease index (OSDI) and OSDI scores (0-100, with 0 representing no symptoms) were calculated for each patient. Medical history, demographics, and concomitant medication information were also collected.Overall, 630 patients from 10 sites participated. Of these, 305 patients (48.4%) had an OSDI score indicating either mild (n = 134, 21.3%), moderate (n = 84, 13.3%), or severe (n = 87, 13.8%) OSD symptoms. OSDI scores were significantly different between patients with and without a prior diagnosis of dry eye syndrome (25.2 +/- 15.4 vs 15.4 +/- 15.8, respectively; P = 0.0036) and between patients who did and did not use artificial tears at the time of study participation (23.0 +/- 15.6 vs 15.3 +/- 15.8, respectively; P = 0.0046). Mean OSDI scores varied significantly with the number of topical IOP-lowering medications used, with higher (more severe) OSDI scores in patients using multiple IOP-lowering medications. Specifically, patients on a single medication had a mean OSDI score of 12.9 +/- 13.1, which was significantly lower than those of patients on 2 (16.7 +/- 17.0; P = 0.007) or 3 medications (19.4 +/- 18.1; P = 0.0001).OSD is prevalent among medically treated patients with glaucoma. The severity of OSD symptoms is positively correlated to the number of IOP-lowering medications used. |
| Databáze: | OpenAIRE |
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