PROSTATE SPECIFIC ANTIGEN KINETICS AT TUMOR RECURRENCE AFTER RADICAL PROSTATECTOMY DO NOT SUGGEST A WORSE DISEASE PROGNOSIS IN BLACK MEN

Autor:	Eric A. Bissonette, Judd W. Moul, Gina R. Petroni, Brant R. Fulmer, Dan Theodorescu
Rok vydání:	2001
Předmět:	Biochemical recurrence medicine.medical_specialty PSA Velocity Prostatectomy business.industry Urology medicine.medical_treatment Retrospective cohort study medicine.disease Surgery Prostate cancer Prostate-specific antigen medicine.anatomical_structure Prostate medicine Stage (cooking) business
Zdroj:	Journal of Urology. 166:1328-1332
ISSN:	1527-3792 0022-5347
DOI:	10.1016/s0022-5347(05)65762-x
Popis:	Purpose: It has been shown that black men with clinically localized prostate adenocarcinoma treated with radical prostatectomy have poorer disease-free and disease specific survival than white men with similar tumors. These findings suggest that a potentially more aggressive variant of prostate cancer exists in black men. Because prostate specific antigen (PSA) velocity at tumor recurrence is a good indicator of disease aggressiveness, we determine whether there was evidence that PSA velocity at biochemical recurrence after radical prostatectomy is faster in black men.Materials and Methods: Our retrospective data search at 2 university centers resulted in 127 white and 37 black men with clinical stage cT1 to 2 prostate adenocarcinoma who underwent radical prostatectomy between 1990 and 1994 and had evidence of biochemical recurrence (PSA greater than 0.2 ng./ml.) on followup available for analysis. No neoadjuvant or adjuvant treatments were given before or after radical prostatectomy, and all PSA relapses...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2938aecf3a101db28903cd8818b9763 https://doi.org/10.1016/s0022-5347(05)65762-x Zobrazit plný text záznamu