Co-transcriptional splicing and the CTD code
| Autor: | Maria Carmo-Fonseca, Noélia Custódio |
|---|---|
| Přispěvatelé: | Repositório da Universidade de Lisboa |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Spliceosome Transcription Genetic viruses RNA Splicing RNA polymerase II Computational biology Biology Splicing environment and public health Biochemistry 03 medical and health sciences Protein Domains Transcription (biology) Gene expression Animals Humans splice Phosphorylation Molecular Biology Regulation of gene expression Genetics CTD code enzymes and coenzymes (carbohydrates) 030104 developmental biology Gene Expression Regulation RNA splicing biology.protein Spliceosomes CTD RNA Polymerase II Transcription Protein Processing Post-Translational |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Critical Reviews in Biochemistry and Molecular Biology |
| ISSN: | 1549-7798 |
| Popis: | © 2016 Informa UK Limited, trading as Taylor & Francis Group. Transcription and splicing are fundamental steps in gene expression. These processes have been studied intensively over the past four decades, and very recent findings are challenging some of the formerly established ideas. In particular, splicing was shown to occur much faster than previously thought, with the first spliced products observed as soon as splice junctions emerge from RNA polymerase II (Pol II). Splicing was also found coupled to a specific phosphorylation pattern of Pol II carboxyl-terminal domain (CTD), suggesting a new layer of complexity in the CTD code. Moreover, phosphorylation of the CTD may be scarcer than expected, and other post-translational modifications of the CTD are emerging with unanticipated roles in gene expression regulation. Authors acknowledge support from Fundação para a Ciência e a Tecnologia, 10.13039/501100001871 [FCT-ANR/BIM-ONC/0009/2013] |
| Databáze: | OpenAIRE |
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