Homeostasis, regeneration and tumour formation in the mammalian epidermis
| Autor: | Fiona M. Watt, Daria Belokhvostova, Geraldine Jowett, Ana-Maria Cujba, Lucy Marshall, Johanna Prueller, Ieva Berzanskyte |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Embryology Skin Neoplasms Cellular differentiation Biology Article 03 medical and health sciences medicine Animals Homeostasis Humans Regeneration Wound Healing Epidermis (botany) Gene Expression Profiling Stem Cells Regeneration (biology) Cancer medicine.disease Stem cell compartment Tumor formation Cell biology 030104 developmental biology Epidermal Cells Epidermis Stem cell Developmental Biology |
| Zdroj: | The International Journal of Developmental Biology. 62:571-582 |
| ISSN: | 0214-6282 |
| DOI: | 10.1387/ijdb.170341fw |
| Popis: | The epidermis is the outer covering of the skin and provides a protective interface between the body and the environment. It is well established that the epidermis is maintained by stem cells that self-renew and generate differentiated cells. In this review, we discuss how recent technological advances, including single cell transcriptomics and in vivo imaging, have provided new insights into the nature and plasticity of the stem cell compartment and the differing roles of stem cells in homeostasis, wound repair and cancer. |
| Databáze: | OpenAIRE |
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