Human platelet antigen 1, 2 and 5 gene polymorphisms in Egyptians and their potential association with susceptibility to immune thrombocytopenic purpura in Egyptian patients
| Autor: | Tayssir Kamel Eyada, Dalia Gamil Amin, Ihab Samih, Salwa Khedr |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adolescent 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Immune system Gene Frequency immune system diseases hemic and lymphatic diseases parasitic diseases medicine Humans Antigens Human Platelet Genetic Predisposition to Disease Prospective Studies Allele Prospective cohort study Gene Allele frequency Alleles Purpura Thrombocytopenic Idiopathic Polymorphism Genetic biology business.industry Incidence (epidemiology) Hematology Middle Aged medicine.disease Thrombocytopenic purpura humanities Human platelet antigen Immunology biology.protein Egypt Female business 030215 immunology |
| Zdroj: | Hematology. 23:111-116 |
| ISSN: | 1607-8454 |
| DOI: | 10.1080/10245332.2017.1365435 |
| Popis: | This study determined the incidence of HPA1, HPA2 and HPA5 polymorphisms in 120 Egyptian immune thrombocytopenic purpura (ITP) patients and 120 healthy Egyptian subjects.Human platelet antigen (HPA) genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism.The frequency of HPA1 allele a and b was 78.75 and 21.25% in controls, 80.8 and 19.2% in ITP, respectively. HPA2 allele a and b frequency was 86.25 and 13.75% in controls and of 74.6 and 25.4% in patients, respectively. HPA5 allele a and b frequency was 87.5 and 12.5% in controls, in patients it was 85 and 15%, respectively. With the exception of HPA2, no other significant difference was encountered in HPA allele frequency between controls and ITP patients.Egyptian HPA profile is closely linked to Middle East and neighboring Arabs. The current study noted that in all the studied HPA systems 1, 2 and 5, the 'a' allele is more prevalent than the b allele; the most frequent genotype was the homozygous a/a genotype. HPA2b frequency, homo- and hetero-zygous HPA2b genotype frequencies were significantly higher in ITP patients compared to controls.HPA 2b are 2.37 times more likely to develop ITP compared to those without this allele. The relatively high allele frequency of the HPA-1b in the Egyptian population suggests that this ethnic group has a higher risk of alloimmunization. |
| Databáze: | OpenAIRE |
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