Taxus canadensis abundant taxane: conversion to paclitaxel and rearrangements
| Autor: | Alice D. Cherestes, Gaétan Caron, Anastasia Nikolakakis, Lolita O. Zamir, Orval A. Mamer, Francoise Sauriol |
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| Rok vydání: | 2000 |
| Předmět: |
Magnetic Resonance Spectroscopy
Taxane Molecular Structure Paclitaxel biology Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Spectrometry Mass Fast Atom Bombardment biology.organism_classification Biochemistry Anticancer drug Trees chemistry.chemical_compound chemistry Baccatin III Drug Discovery Chemical reduction Taxus canadensis Molecular Medicine Diterpene Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry. 8:1269-1280 |
| ISSN: | 0968-0896 |
| Popis: | An efficient conversion of Taxus canadensis abundant taxane, 9-dihydro-13-acetylbaccatin III to baccatin III is described. Since the synthesis of paclitaxel from baccatin III has been reported, this work can be used for additional supply of this powerful anticancer drug. In addition, new taxanes derived from skeletal rearrangements originating from oxidation–reduction reactions of the Canadian yew major taxane, are reported. |
| Databáze: | OpenAIRE |
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