Influence of dental restoration under general anaesthesia on the low-dose dexamethasone suppression test in dogs
| Autor: | Stefanie Hoffrogge, Marion Schmicke, Reinhard Mischke |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Adrenocortical Hyperfunction Hydrocortisone 040301 veterinary sciences medicine.medical_treatment Reference range Low dose dexamethasone suppression test Anesthesia General Dexamethasone 0403 veterinary science 03 medical and health sciences Basal (phylogenetics) Dogs medicine Animals General anaesthesia Dog Diseases Glucocorticoids 030304 developmental biology 0303 health sciences Dose-Response Relationship Drug General Veterinary business.industry 04 agricultural and veterinary sciences Minor surgery Anesthesia Dexamethasone suppression test Female Dental Restoration Repair business Dental restoration medicine.drug |
| Zdroj: | Research in Veterinary Science. 129:117-119 |
| ISSN: | 0034-5288 |
| DOI: | 10.1016/j.rvsc.2020.01.002 |
| Popis: | It was the aim of the study to assess the impact of a minor surgical intervention under general anaesthesia on results of a low-dose dexamethasone suppression test (LDDST) in dogs. Five clinically healthy dogs underwent a LDDST (standard protocol) prior and 1, 4, 7, 14 and 28 days after a dental restoration under general anaesthesia. All LDDSTs revealed negative results. On all test days after intervention some dogs had basal cortisol concentrations below the reference range. Accordingly, plasma cortisol concentrations 4 and 8 h after dexamethasone injection were noticeably lower than before surgery and often even below the lower detection limit of 2.0 ng/ml. The study results may indicate a suppressive effect of a minor surgery under general anaesthesia on cortisol measurements during LDDSTs. It may be speculated that this could possibly lead to false negative test results in the postsurgical period, although transfer of these results to clinical cases is subject to limitations. |
| Databáze: | OpenAIRE |
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