Prognostic significance of CD9 expression in locally advanced gastric cancer treated with surgery and adjuvant chemoradiotherapy
| Autor: | Işın Soyuer, Okan Orhan, Kadir Ucar, Dilek Unal, Oğuz Galip Yildiz, Serdar Soyuer |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty medicine.medical_treatment Kaplan-Meier Estimate Adenocarcinoma Disease-Free Survival Tetraspanin 29 Pathology and Forensic Medicine Young Adult Antigens CD Stomach Neoplasms Internal medicine Biomarkers Tumor medicine Humans Young adult Digestive System Surgical Procedures Aged Neoplasm Staging Proportional Hazards Models Chemotherapy Membrane Glycoproteins Radiotherapy Proportional hazards model business.industry Cancer Cell Biology Middle Aged Prognosis medicine.disease Immunohistochemistry Surgery Radiation therapy Chemotherapy Adjuvant embryonic structures Monoclonal Neoplastic cell Female business |
| Zdroj: | Pathology - Research and Practice. 206:607-610 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/j.prp.2010.04.004 |
| Popis: | The tetraspanin transmembrane protein CD9 plays an important role in inhibiting cell motility in numerous neoplastic cell lines, including lung, gastric, pancreatic, and bladder carcinomas. The prognostic importance of CD9 in the survival of gastric carcinoma patients has not been examined to date, and in the present study, we attempted to define its prognostic value. The study included 49 (35 men and 14 women) patients with locally advanced (stages II-IV) gastric cancer. The median age was 55 years (range, 22-73 years). Surgery was the initial treatment for all patients, followed by adjuvant chemoradiotherapy. Tissue sections were evaluated immunohistochemically with a monoclonal anti-CD9 antibody. Of the 49 patients with gastric adenocarcinoma, 11 (22.4%) were CD9-positive, and 38 (77.6%) were CD9-negative. A significant prognostic value in disease-free survival and overall survival was observed in T classification and CD9 positivity. In conclusion, CD9 expression in gastric cancer appears to be associated with poor prognosis. |
| Databáze: | OpenAIRE |
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