Dienogest vs GnRH agonists as postoperative therapy after laparoscopic eradication of deep infiltrating endometriosis with bowel and parametrial surgery: a randomized controlled trial
| Autor: | Agnese Donati, Stefano Liverani, Marcello Ceccaroni, Giovanni Roviglione, Roberto Clarizia, M Manzone, M Ceccarello, Simone Ferrero |
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| Rok vydání: | 2021 |
| Předmět: |
Reoperation
medicine.medical_specialty Endocrinology Diabetes and Metabolism Endometriosis 030209 endocrinology & metabolism Reproductive physiology Pelvic Pain law.invention Gonadotropin-Releasing Hormone 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Randomized controlled trial Postoperative treatment law Pregnancy Recurrence medicine Secondary Prevention Humans Nandrolone Postoperative Care 030219 obstetrics & reproductive medicine Triptorelin Pamoate Parametrial business.industry Obstetrics and Gynecology medicine.disease Deep infiltrating endometriosis Surgery Intestines Treatment Outcome Dienogest chemistry Surgical excision Female Laparoscopy Leuprolide Peritoneum business |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 37(10) |
| ISSN: | 1473-0766 |
| Popis: | The recurrence of deep infiltrating endometriosis (DIE) after its surgical excision is a big problem: postoperative treatment is crucial.To compare two postoperative treatments: Dienogest and GnRH agonists.Prospective Randomized Controlled Trial (RCT).146 women submitted to laparoscopic eradication of DIE with bowel and parametrial surgery.Patients were randomized into two groups. Group A (The primary outcome was to demonstrate the non-inferiority of Dienogest about the reduction in pain recurrence. Secondary outcomes were differences in terms of treatment tolerability, side effects, imaging relapse rate, and pregnancy rate.Both Dienogest and GnRH agonists were associated with a highly significant reduction of pain at 6 and 30 months, without any significant difference (Dienogest has proven to be as effective as GnRH agonists in preventing recurrence of DIE and associated pelvic pain after surgery. Also, it is better tolerated by patients. |
| Databáze: | OpenAIRE |
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