Neurofibromin Expression is Associated with Aggressive Disease and Poor Outcome in Colorectal Carcinoma
| Autor: | Fatma Emaetig, Matti Latto, Fairouz Torjman, Adam Elzagheid, Yrjö Collan, Wesam A. Elsaghayer, Seppo Pyrhönen, Kari Syrjänen |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Male Cancer Research Pathology medicine.medical_specialty Colorectal cancer Rectum Kaplan-Meier Estimate Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Adjuvant therapy Biomarkers Tumor Humans Lymph node Grading (tumors) Aged ta3126 Neurofibromin 1 biology business.industry General Medicine medicine.disease ta3122 Prognosis 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Immunohistochemistry Female business Colorectal Neoplasms |
| Zdroj: | Anticancer research. 36(10) |
| ISSN: | 1791-7530 |
| Popis: | Aim: To assess the predictive and prognostic value of neurofibromin (NF) expression in colorectal carcinoma (CRC). Materials and Methods: The present series consists of archival samples from 191 patients with stage I, II, III, or IV CRC treated between 1981 and 1990 at the Turku University Hospital (Finland). Tumor biopsies as microarray blocks were analyzed for expression of NF by immunohistochemistry. Different grading systems were tested for NF expression. Results: A significant correlation between NF expression and tumor localization was found, with tumors arising in the colon showing intense NF expression more often than those arising in the rectum (p=0.014). Higher expression of NF was more common in tumors not responding to treatment (p=0.004). Tumors with multiple metastases showed higher expression of NF than those with single metastasis only (p=0.025). Furthermore, NF expression showed a borderline (p=0.068) correlation with gender; tumors of women showed higher NF expression that those of males. On the other hand, NF expression was not significantly associated with tumor recurrence, age, lymph node involvement, tumor grade and tumor stage or disease outcome. Conclusion: Positive NF expression in CRC is a sign of aggressive disease and poor outcome. |
| Databáze: | OpenAIRE |
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