Prebiotic and Probiotic Fortified Milk in Prevention of Morbidities among Children: Community-Based, Randomized, Double-Blind, Controlled Trial
| Autor: | Sunil Sazawal, Usha Dhingra, Archana Sarkar, Pratibha Dhingra, Arup Dutta, Girish Hiremath, Venugopal P. Menon, Robert E. Black |
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| Rok vydání: | 2010 |
| Předmět: |
Pediatrics
medicine.medical_specialty Time Factors Anemia Iron Health Behavior Pediatrics and Child Health Public Health and Epidemiology lcsh:Medicine Breast milk law.invention Blood serum Double-Blind Method Randomized controlled trial law medicine Animals Humans Micronutrients lcsh:Science Nutrition Multidisciplinary biology business.industry lcsh:R Infant Public Health and Epidemiology/Global Health medicine.disease Ascorbic acid Micronutrient Pediatrics and Child Health/Child Development Nutrition/Deficiencies Nutrition/Malnutrition Ferritin Milk Iron-deficiency anemia Child Preschool Food Fortified biology.protein lcsh:Q Growth and Development business Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 5, Iss 8, p e12167 (2010) |
| ISSN: | 1932-6203 |
| Popis: | Background Multiple micronutrient deficiencies are highly prevalent among preschool children and often lead to anemia and growth faltering. Given the limited success of supplementation and health education programs, fortification of foods could be a viable and sustainable option. We report results from a community based double-masked, randomized trial among children 1–4 years evaluating the effects of micronutrients (especially of zinc and iron) delivered through fortified milk on growth, anemia and iron status markers as part of a four group study design, running two studies simultaneously. Methods and Findings Enrolled children (n = 633) were randomly allocated to receive either micronutrients fortified milk (MN = 316) or control milk (Co = 317). Intervention of MN milk provided additional 7.8 mg zinc, 9.6 mg iron, 4.2 µg selenium, 0.27 mg copper, 156 µg vitamin A, 40.2 mg vitamin C, and 7.5 mg vitamin E per day (three serves) for one year. Anthropometry was recorded at baseline, mid- and end-study. Hematological parameters were estimated at baseline and end-study. Both groups were comparable at baseline. Compliance was over 85% and did not vary between groups. Compared to children consuming Co milk, children consuming MN milk showed significant improvement in weight gain (difference of mean: 0.21 kg/year; 95% confidence interval [CI] 0.12 to 0.31, p |
| Databáze: | OpenAIRE |
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