Muscle contraction increases palmitate esterification and oxidation and triacylglycerol oxidation
| Autor: | D. J. Dyck, Arend Bonen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Physiology Endocrinology Diabetes and Metabolism Glyceride Palmitic Acid In Vitro Techniques Glycerides Diglycerides Rats Sprague-Dawley Palmitic acid Hydrolysis chemistry.chemical_compound Physiology (medical) Internal medicine medicine Animals Muscle Skeletal Phospholipids Triglycerides Diacylglycerol kinase Glycogen Oxidation reduction Metabolism Electric Stimulation Rats Kinetics Glucose Endocrinology chemistry Female medicine.symptom Energy Metabolism Oxidation-Reduction Muscle Contraction Muscle contraction |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 275:E888-E896 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1998.275.5.e888 |
| Popis: | We examined the oxidation and esterification of palmitate and the hydrolysis and oxidation of intramuscular lipids in isolated soleus muscles at rest and during tetanic contractions (2–40 tetani/min). Muscles were pulsed with [14C]palmitate to prelabel all intramuscular lipid pools. Muscles remained at rest or were then stimulated to contract at 2, 8, 20, or 40 tetani/min (30 min) in the presence of [3H]palmitate. Palmitate oxidation was increased 412% at 2 tetani/min ( P < 0.05) and 880% at 8 tetani/min ( P < 0.05). During contraction there was an absolute increase in esterification of palmitate to triacylglycerol in proportion with the increasing rate of palmitate oxidation. Intramuscular lipid oxidation provided ∼77% of the total muscle energy compared with ∼3% provided by exogenous palmitate under all conditions, with carbohydrate sources (glycogen and glucose) providing ∼20% of the total energy. Thus, during muscle contraction, the oxidation rates of both exogenous and intramuscular lipids are increased in proportion to each other, while concomitantly palmitate is esterified in proportion to its oxidation. |
| Databáze: | OpenAIRE |
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