1719P Clinical characteristics and 28-day mortality among patients with solid cancers and COVID-19 in a tertiary hospital
| Autor: | Jose Carlos Tapia, J. Gavira, M. Riudavets, Margarita Majem, Ignasi Gich, Oscar J. Ponce, Agust Barnadas |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Hazard ratio Cancer Retrospective cohort study Hydroxychloroquine Hematology Overweight medicine.disease Azithromycin Article chemistry.chemical_compound Tocilizumab Oncology Respiratory failure chemistry Internal medicine medicine medicine.symptom business medicine.drug |
| Zdroj: | Europe PubMed Central Annals of Oncology |
| ISSN: | 0923-7534 |
| Popis: | Background: The impact of coronavirus disease 2019 (COVID-19) on cancer patients is still unknown We aimed to describe the clinical characteristics and 28-day mortality among patients with solid cancers (SC) and COVID-19 Methods: This single-center retrospective study included all adult patients with SC and RT-PCR confirmed COVID-19 between March 12, 2020 and April 30, 2020 Both oncological and COVID-19-related clinical data were collected COVID-19 severity was defined according to Chinese CDC criteria In-hospital and 28-day mortality were estimated Multivariate analysis was adjusted for age, sex and COVID-19 severity Results: We included 58 (2 7%) of 2130 patients with COVID-19 diagnosed in our hospital;37 (63 8%) were males Median age was 68 5 years (IQR, 61-75) Main comorbidities were hypertension (28 [48 3%]) and overweight/obesity (23 [39 7%]) Most common SC were prostate (12 [20 7%]), lung (10 [17 2%]) and breast (10 [17 2%]) Overall, 48 (82 8%) patients had previous ECOG PS of 0-1;26 (44 8%) were stage IV and 32 (57 1%) were undergoing cancer treatment Fifty-six (96 5%) patients were admitted Most frequent COVID-19 symptoms were fever (40 [69 0%]), cough (35 [62 5%]) and dyspnea (27 [48 2%]) Hydroxychloroquine and azithromycin were used in 40 (69 0%) and 38 (65 5%) patients, respectively;only 3 (5 2%) patients received tocilizumab Eighteen patients (32 1%) had severe/critical COVID-19 Major complications were respiratory failure (33 [57 9%]), sepsis (14 [24 6%]) and acute kidney injury (13 [22 4%]) Four (6 9%) patients were admitted to ICU In-hospital and 28-day mortality were 17 2% (10/58) and 24 1% (14/58), respectively In the multivariate analysis, only dyspnea at diagnosis (hazard ratio [HR]: 6 71, 95% CI 1 40-32 25, p=0 017) and ECOG PS of 2-3 (HR: 4 17;95% CI: 1 13-15 30, p=0 031) were independent risk factors for 28-day mortality Conclusions: In our patients with SC and COVID-19, 32 1% had a severe/critical disease and 24 1% died within 28 days from diagnosis Dyspnea at diagnosis and previous ECOG PS of 2-3 were the major predictors for 28-day mortality Cancer treatment and stage were not associated with mortality Legal entity responsible for the study: The authors Funding: Has not received any funding Disclosure: M Majem: Honoraria (self), Research grant/Funding (self): BMS;Honoraria (self), Non-remunerated activity/ies: MSD;Honoraria (self), Non-remunerated activity/ies: BOEHRINGER INGELHEIM;Honoraria (self), Non-remunerated activity/ies: ASTRA ZENENCA;Honoraria (self), Non-remunerated activity/ies: KYOWA KYRIN;Honoraria (self): PIERRE FABRE All other authors have declared no conflicts of interest |
| Databáze: | OpenAIRE |
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