Biological variation of arginine vasopressin
| Autor: | Samuel N. Cheuvront, Kurt J. Sollanek, Jeffery S. Staab, Robert W. Kenefick |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Vasopressin medicine.medical_specialty Adolescent Arginine Physiology Organism Hydration Status Young Adult Mild dehydration Physiology (medical) Internal medicine Biological variation Healthy volunteers medicine Humans Orthopedics and Sports Medicine Hydration status business.industry Public Health Environmental and Occupational Health General Medicine Human physiology Plasma levels Healthy Volunteers Arginine Vasopressin Endocrinology Female business Algorithms hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Applied Physiology. 120:635-642 |
| ISSN: | 1439-6327 1439-6319 |
| DOI: | 10.1007/s00421-020-04303-x |
| Popis: | There is growing interest in the measurement of plasma levels of arginine vasopressin (AVP) for the assessment of mild dehydration. However, the principles of biological variation have not been applied to the study of AVP and understanding biological variation of AVP may provide insights regarding measurement thresholds. The purpose of this investigation was to determine the biological variation of AVP in healthy euhydrated individuals to understand the potential for establishing both static and/or change thresholds of importance. We studied 29 healthy volunteers (24 men and 5 women) while controlling for hydration and pre-analytical factors. All subjects completed between 2–8 trials where biological variation was determined using widely published methods. We determined the intraindividual, interindividual, and analytical coefficients of variation (CVI, CVG, and CVA, respectively) and subsequently the index of individuality and heterogeneity (II and IH, respectively). AVP did not reach the IH threshold required to be considered useful in the dynamic assessment of physiological deviations from normal. AVP levels approached the II threshold required to be considered useful in the static assessment of physiological deviations from normal. This analysis demonstrates that AVP assessment is unlikely to yield useful information about hydration status. |
| Databáze: | OpenAIRE |
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