The Pattern of Proline, Glutamic Acid, and Leucine-Rich Protein 1 Expression in Chinese Women with Primary Breast Cancer
| Autor: | Ying Ma, Lunshu Guo, Mumu Shi, Peng Wang, Yanzhi Zhang, Jiali Dai, Hironobu Sasano, Ming Liu, Xiaoyan Wang, Lin Wang, Monica S.M. Chan |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
China Cancer Research medicine.medical_specialty Proline Clinical Biochemistry Glutamic Acid Breast Neoplasms Biology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Biomarkers Tumor medicine Humans skin and connective tissue diseases Gene Regulation of gene expression Glutamic acid Prognosis medicine.disease Gene Expression Regulation Neoplastic Treatment Outcome 030104 developmental biology Endocrinology Oncology Biochemistry 030220 oncology & carcinogenesis Immunohistochemistry Female Leucine Primary breast cancer Co-Repressor Proteins Transcription Factors |
| Zdroj: | The International Journal of Biological Markers. 29:e1-e7 |
| ISSN: | 1724-6008 |
| DOI: | 10.5301/jbm.5000078 |
| Popis: | Background Disparities of biomarkers’ expression in breast cancer across different races and ethnicities have been well documented. Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a novel ER coregulator, has been considered as a promising biomarker of breast cancer prognosis; however, the pattern of PELP1 expression in Chinese women with breast cancer has never been investigated. This study aims to provide useful reference on possible racial or ethnic differences of PELP1 expression in breast cancer by exploring the pattern of PELP1 expression in Chinese women with primary breast cancer. Methods The expression of PELP1 in primary breast cancer samples from 130 Chinese female patients was detected by immunohistochemistry and correlated to other clinicopathological parameters; for comparison, the expression of PELP1 in 26 benign breast fibroadenomas was also examined. Results The overall value of the PELP1 H-score in breast cancer was significantly higher than that in breast fibroadenoma (pConclusion Overexpression of PELP1 in Chinese women with primary breast cancer appears to be associated with biomarkers of poor outcome; these results are similar to other reports based on Western populations. |
| Databáze: | OpenAIRE |
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