Public health research needs for molecular epidemiology and to emphasize homeostasis - could the omnipotent endopeptidase inhibitor α-2-macroglobulin be a meaningful biomarker?
| Autor: | Pattara Sanchaisuriya, Frank Peter Schelp, Ratthaphol Kraiklang, Benja Muktabhant, Pornpimon Chupanit |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Gerontology medicine.medical_specialty Population Population health General Biochemistry Genetics and Molecular Biology metabolic syndrome 03 medical and health sciences 0302 clinical medicine Overnutrition Pregnancy Epidemiology Endopeptidases medicine Homeostasis Humans 030212 general & internal medicine Prospective Studies General Pharmacology Toxicology and Pharmaceutics education education.field_of_study Molecular Epidemiology General Immunology and Microbiology Molecular epidemiology business.industry Public health dietary restriction General Medicine Articles Opinion Article medicine.disease sustainable development goals Obesity non-communicable diseases Pregnancy-Associated alpha 2-Macroglobulins 030104 developmental biology Biomarker (medicine) Female Public Health business alpha-2-macroglobulin Biomarkers |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| Popis: | Public health authorities in low- and middle-income countries face dramatic challenges in handling rapidly increasing non-communicable diseases (NCDs), due to the epidemiological- and particularly nutritional transition. Among major reasons for the development of NCDs are smoking and alcohol, but overnutrition and obesity are also major threats to population health. Obesity is related to diabetes and cancer, but also has a genetic background. It is difficult to recommend a healthy nutrition. This is because of conflicting nutritional conceptions, and given the complexity of human metabolism understanding this topic can be difficult for the laymen. Public health measures advocating physical activity and refraining from high intake of energy, sugar and soft drinks need to be enhanced by supporting the ‘intrinsic motivation’ to preserve a good health. The mission of public health should be to increase awareness about the complexity of human metabolism, and the involvement of genetic and epigenetics in health and diseases. To maintain homeostasis, means to keep an optimal relationship between catabolism and synthesis, seems to be of particular interest. Preconditions for this is, that public health institutions within the administration- and academic sector follow up developments in life science and molecular biology and conduct population-based research making use of molecular epidemiology, especially those related to key metabolic steps and maintenance of ‘homeostasis’, in balancing catabolism and anabolism. A prospective biomarker for this situation might be α-2-macroglobulin. |
| Databáze: | OpenAIRE |
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