Chronopharmacokinetics and cardiovascular effects of nifedipine
| Autor: | Björn Lemmer, Roland Kaiser, Gudrun Nold, Susanne Behne |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Ambulatory blood pressure Nifedipine Physiology Cmax Hemodynamics Administration Oral Blood Pressure Pharmacology Pharmacokinetics Heart Rate Physiology (medical) Internal medicine medicine Humans Circadian rhythm Infusions Intravenous business.industry Blood flow Circadian Rhythm Endocrinology Blood pressure Delayed-Action Preparations business medicine.drug Liver Circulation |
| Zdroj: | Chronobiology international. 8(6) |
| ISSN: | 0742-0528 |
| Popis: | Circadian phase dependency in pharmacokinetics and hemodynamic effects on blood pressure and heart rate of different galenic formulations of nifedipine (immediate-release, sustained-release, and i.v. solution) were studied in healthy subjects or in hypertensive patients. Pharmacokinetics of immediate-release but not sustained-release and i.v. nifedipine were dependent on time of day: immediate-release nifedipine had higher Cmax (peak concentration) and shorter tmax (time-to-peak concentration) after morning than evening application, and bioavailability in the evening was reduced by about 40%. Circadian rhythm in estimated hepatic blood flow as determined by indocyanine green kinetics may contribute to these chronokinetics. A circadian time dependency was also found in nifedipine-induced effects on blood pressure and heart rate as monitored by 24-h ambulatory blood pressure measurements. In conclusion, the dose response relationship of oral nifedipine is influenced by the circadian organization of the cardiovascular system as well as by the galenic drug formulation. |
| Databáze: | OpenAIRE |
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