Monte Carlo modelling of photodynamic therapy treatments comparing clustered three dimensional tumour structures with homogeneous tissue structures
| Autor: | Harry Moseley, C L Campbell, Christian T. A. Brown, Kenneth Wood |
|---|---|
| Přispěvatelé: | Science & Technology Facilities Council, University of St Andrews. School of Physics and Astronomy |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
medicine.medical_treatment Monte Carlo method NDAS Photodynamic therapy Three dimensional modelling R Medicine 01 natural sciences Fluence Models Biological 010309 optics Fractal Optics Neoplasms 0103 physical sciences medicine Effective treatment Humans Radiology Nuclear Medicine and imaging 010303 astronomy & astrophysics QC Radiological and Ultrasound Technology business.industry Monte Carlo modelling Radiotherapy Dosage Fluorescence Fluorescence intensity QC Physics Fractals Photochemotherapy Homogeneous business Monte Carlo Method Biomedical engineering |
| Zdroj: | Physics in medicine and biology. 61(13) |
| ISSN: | 1361-6560 |
| Popis: | C L Campbell acknowledges financial support from an UK EPSRC PhD studentship (EP/K503162/1) and the Alfred Stewart Trust. We explore the effects of three dimensional (3D) tumour structures on depth dependent fluence rates, photodynamic doses (PDD) and fluorescence images through Monte Carlo radiation transfer modelling of photodynamic therapy. The aim with this work was to compare the commonly used uniform tumour densities with non-uniform densities to determine the importance of including 3D models in theoretical investigations. It was found that fractal 3D models resulted in deeper penetration on average of therapeutic radiation and higher PDD. An increase in effective treatment depth of 1 mm was observed for one of the investigated fractal structures, when comparing to the equivalent smooth model. Wide field fluorescence images were simulated, revealing information about the relationship between tumour structure and the appearance of the fluorescence intensity. Our models indicate that the 3D tumour structure strongly affects the spatial distribution of therapeutic light, the PDD and the wide field appearance of surface fluorescence images. Postprint |
| Databáze: | OpenAIRE |
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