Activity of N-acetyl-β-hexosaminidase and its isoenzymes A and B in cancer
| Autor: | Jacek Janica, Sławomir Dariusz Szajda, Krzysztof Zwierz, Jacek Dadan, Ladny, Luto M, Barbara Choromańska, Alina Kępka, Napoleon Waszkiewicz, Piotr Myśliwiec |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
Glycoconjugate żołądek lcsh:Medicine jelito grube Isozyme Hexosaminidase A Glycolipid Hexosaminidase B Neoplasms rak Biomarkers Tumor medicine Humans Hexosaminidase Glycoproteins Glycosaminoglycans chemistry.chemical_classification nerka integumentary system Isoelectric focusing lcsh:R Cancer N-acetylo-β-D-heksozoaminidaza Oligosaccharide trzustka medicine.disease Molecular biology Isoenzymes carbohydrates (lipids) HEX B Infectious Diseases chemistry HEX A embryonic structures Poland Glycolipids Glycoprotein |
| Zdroj: | Postępy Higieny i Medycyny Doświadczalnej, Vol 65, Iss 846636, Pp 752-758 (2011) |
| ISSN: | 1732-2693 |
| DOI: | 10.5604/17322693.966833 |
| Popis: | There were approximately 93,060 deaths from cancers in Poland in 2008, and about 105,000 are predicted for the year 2025. Early detection of cancer is a major problem throughout the world, which is why many researchers are still looking for specific and sensitive markers of malignant tumors. Our work is a review of recent publications on activity of N-acetyl-β-D-hexosaminidase (HEX) and its isoenzymes A (HEX A) and B (HEX B) as potential markers of malignant tumors. HEX is the most active of the lysosomal exoglycosidases, taking part in degradation of glycoconjugates (glycoproteins, glycolipids, proteoglycans). HEX cleaves N-acetyl-D-glucosamine and N-acetyl-D-galactosamine from non-reducing ends of oligosaccharide chains of glycoproteins, glycolipids and glycosaminoglycans. The activity of HEX, and its isoenzymes A (HEX A) and B (HEX B), was determined by spectrophotometric and isoelectric focusing methods. There was a statistically significant increase in activity of HEX in tumors of the kidney, pancreas, thyroid, colon, ovary, brain, salivary gland, stomach and larynx, which suggests potential applicability of HEX and its isoenzymes in cancer diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|