The Immune Microenvironment in Breast Carcinoma: Predictive and Prognostic Role in the Neoadjuvant Setting
| Autor: | Fedor Berditchevski, Nahla M Badr, Abeer M Shaaban |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Immune microenvironment
medicine.medical_treatment Cell Breast Neoplasms Triple Negative Breast Neoplasms Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Immune system Lymphocytes Tumor-Infiltrating Biomarkers Tumor Tumor Microenvironment Medicine Humans Molecular Biology Pathological Chemotherapy business.industry Cell Biology General Medicine medicine.disease Prognosis Neoadjuvant Therapy medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer cell Cancer research Female business Breast carcinoma Infiltration (medical) 030215 immunology Signal Transduction |
| Zdroj: | Pathobiology : journal of immunopathology, molecular and cellular biology. 87(2) |
| ISSN: | 1423-0291 |
| Popis: | The prognostic value of the immune cell infiltrate in the breast carcinoma microenvironment is still uncertain. We reviewed published articles analysing the infiltration of inflammatorycells in the microenvironment of breast carcinoma. Data revealed the importance of infiltration of these immune cells in the prognosis of breast carcinoma, particularly the triple-negative and HER2-positive phenotypes. Tumour-infiltrating lymphocytes and their subtypes play a fundamental role in predicting the pathological complete response (pCR) to neoadjuvant chemotherapy. More research aiming to dissect a complex network of communication between cancer cells and other cellular components of the tumour microenvironment is necessary to develop more effective therapeutic approaches. |
| Databáze: | OpenAIRE |
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