Investigation of the pharmacokinetics of cyclosporine in patients following long-term administration after a kidney transplant: comparison of neoral and sandimmune
| Autor: | Yasuyuki Kojima, Norio Nonomura, Kazuhiro Yoshimura, Kiyomi Matsumiya, Shiro Takahara, Akihiko Okuyama, Yi Shi, Kiyohide Toki, Naotsugu Ichimaru, Yukiomi Namba |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Chemistry Pharmaceutical Urinary system Urology Drug Administration Schedule Maintenance therapy Pharmacokinetics medicine Humans In patient Kidney transplantation Transplantation business.industry Middle Aged medicine.disease Ciclosporin Kidney Transplantation Surgery Area Under Curve Cyclosporine Female business Adverse drug reaction medicine.drug |
| Zdroj: | Transplantation Proceedings. 36:S456-S460 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2004.01.065 |
| Popis: | A crossover administration of Neoral and Sandimmune was performed in 43 renal allograft recipients who had been on cyclosporine maintenance therapy for 2 to 19 years posttransplant to investigate the pharmacokinetics of cyclosporine. Although there was no difference in C0 values (trough values) when Neoral and Sandimmune were administered at the same doses, AUC(0-4) and AUC(0-12) values of Neoral were 1.57- and 1.36-fold greater than those of Sandimmune, respectively. For both Neoral and Sandimmune, there was a high correlation between the C2 value and AUC(0-4). The Pearson's product-moment coefficient for the correlation between the C2 value and AUC(0-4) was R=0.91642. On the other hand, the correlation with the C0 value (trough value) was low (R=0.53181). During the period of the study, there was no acute rejection episode, onset of adverse drug reaction symptoms, or marked change in laboratory test values. |
| Databáze: | OpenAIRE |
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