The effect of peripheral blood eosinophilia on inflammatory markers in asthmatic patients with lower respiratory tract infections
| Autor: | Mehmet Gunduz, Arif Kut, Sadik Erhan Ozaydin, Mustafa Özçetin, Yakup Pacal, Necmettin Toprak, Birgul Altinsoy Kertmen, Sakine Isik, Yakup Cag |
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| Přispěvatelé: | Maltepe Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Medicine (General) Clinical Research Reports Neutrophils Biochemistry Lower respiratory tract infection 03 medical and health sciences R5-920 0302 clinical medicine neutrophil-to-lymphocyte ratio Predictive Value of Tests Inflammatory marker Eosinophilia medicine Asthmatic patient Humans peripheral blood eosinophilia 030212 general & internal medicine Lymphocytes Neutrophil to lymphocyte ratio Respiratory Tract Infections Retrospective Studies Inflammation Respiratory tract infections business.industry Biochemistry (medical) fungi Allergic asthma Cell Biology General Medicine medicine.disease Asthma Paediatric asthma C-Reactive Protein Cross-Sectional Studies 030228 respiratory system Immunology Peripheral Blood Eosinophilia Disease Progression Female Inflammation Mediators business allergic asthma Biomarkers Follow-Up Studies |
| Zdroj: | The Journal of International Medical Research Journal of International Medical Research, Vol 47 (2019) |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | WOS: 000471695200014 PubMed ID: 31006357 Background To investigate the behaviour of the inflammatory marker neutrophil-to-lymphocyte ratio (NLR) in the presence of peripheral blood eosinophilia (PBE) in paediatric asthma patients with lower respiratory tract (LRT) infections. Methods This retrospective study enrolled consecutive patients aged >= 5 years who were diagnosed with asthma and whose haemogram values were available. The patients were further subdivided based on the presence or absence of LRT infections and allergies. NLR and C-reactive protein (CRP) were evaluated in relation to the presence or absence of PBE (>= 4% eosinophils). Results A total of 991 patients were enrolled in the study. Patients with LRT infections had significantly higher leucocyte and neutrophil counts, a greater NLR and a higher level of CRP compared with patients without LRT infections. Overall, patients with PBE had significantly lower NLRs and CRP regardless of the presence or absence of an LRT infection. The PBE percentage showed moderate inverse correlations with NLR (r = -0.34) and CRP (r = -0.20). Conclusion The presence of PBE was significantly associated with lower NLR and CRP regardless of the presence or absence of an infectious condition. |
| Databáze: | OpenAIRE |
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